Exploring the potential of the nano-based sunscreens and antioxidants for preventing and treating skin photoaging

Lin, Chih-Hung; Lin, Ming-Hsien; Chung, Yu-Kuo; Alalaiwe, Ahmed; Hung, Chi-Feng; Fang, Jia-You

doi:10.1016/j.chemosphere.2023.140702

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2024

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Cited by 3 publications

References 167 publications

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Specific Knockdown of the NDUFS4 Gene Reveals Important Roles of Ferroptosis in UVB-induced Photoaging

Teng,

Cui,

et al. 2024

Inflammation

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Specific Knockdown of the NDUFS4 Gene Reveals Important Roles of Ferroptosis in UVB-induced Photoaging

Teng,

Cui,

et al. 2024

Inflammation

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Exposure to UV-B filter octylmethoxycinnamate and human health effects: Focus on endocrine disruptor actions

Lorigo,

Quintaneiro,

Breitenfeld

et al. 2024

Chemosphere

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Specific knockdown of the NDUFS4 gene reveals important roles of Ferroptosis in UVB-induced photoaging

Yan,

Cui,

et al. 2024

Preprint

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Ultraviolet (UV) irradiation significantly contributes to photoaging. Ferroptosis, an iron-dependent cell death mode recently identified, plays a key role in UVB-induced skin photoaging. This study examines the functions and regulatory mechanisms of ferroptosis in this regard. Characterized by increased intracellular iron and reactive oxygen species (ROS), ferroptosis is associated with mitochondrial function and structure. Through RNA sequencing, we identified NADH: ubiquinone oxidoreductase subunit S4 (NDUFS4), a gene implicated in UVB-mediated photoaging, and explored its role in ferroptosis by NDUFS4 knockdown. In vitro, inhibiting NDUFS4 reduced ferroptosis, decreased ROS levels, and increased glutathione peroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1), and solute carrier family 7 member 11 (SLC7A11) levels, suggesting a reinforced ferroptosis protective mechanism. Additionally, NDUFS4 regulates ferroptosis via the mitogen-activated protein kinase (MAPK) pathway, with its knockdown reducing p38 and ERK phosphorylation and elevating GPX4 levels, enhancing ferroptosis resistance. Animal experiments supported these findings, demonstrating that Fer-1, a ferroptosis inhibitor, significantly mitigated UVB-induced skin photoaging and related protein expression. This study uncovers NDUFS4's novel role in regulating ferroptosis and provides new insights into ferroptosis-mediated UVB-induced skin photoaging.

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Exploring the potential of the nano-based sunscreens and antioxidants for preventing and treating skin photoaging

Cited by 3 publications

References 167 publications

Specific Knockdown of the NDUFS4 Gene Reveals Important Roles of Ferroptosis in UVB-induced Photoaging

Specific Knockdown of the NDUFS4 Gene Reveals Important Roles of Ferroptosis in UVB-induced Photoaging

Exposure to UV-B filter octylmethoxycinnamate and human health effects: Focus on endocrine disruptor actions

Specific knockdown of the NDUFS4 gene reveals important roles of Ferroptosis in UVB-induced photoaging

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