Exploring the Potential of Substituted 4-Thiazolidinone Derivatives in the Treatment of Breast Cancer: Synthesis, Biological Screening and <i>In Silico</i> Studies

Teli, Ghanshyam; Sharma, Priyanka; Chawla, Pooja

doi:10.1080/10406638.2022.2112708

Cited by 5 publications

(5 citation statements)

References 45 publications

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“…[43] Natural products, colours, medicines, organic materials, and notably pharmacologically promising compounds all include N-heterocycles. [4,44] These N-heterocyclic compounds such as triazine, [45] indole, [46] oxadiazole, [47] acridine, [48] benzimidazoles, [49] benzothiazoles, [50] imidazole, [51] isoxazole, [52] thiazolidine, [53] triazoles, [54] quinolines, [55] pyrimidine, [56] pyrazole [57] and quinazolines garnered a lot of interest in recent years due to their wide range of activities. [58] These N-heterocyclic described anticancer effects in numerous types of cancer through limiting cell growth, inducing cell differentiation and apoptosis.…”

Section: Importance Of Nitrogen Containing Heterocyclic Compound As E...mentioning

confidence: 99%

Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships

Pal¹,

Teli²,

Matada³

et al. 2023

ChemistrySelect

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proved to be the magical weapon in designed and discovery of synthetic molecules as they acquired comprehensive range of pharmacological properties. In recent year (2018-2022) Nheterocyclic derivatives were uncovered as the potential EGFR TKIs. The present review summarised the research progress of EGFR TKIs to dazed the limitations of currently accessible drugs by consecrating, anatomy, mutation of EGFR, and its role in different types of cancer. The review highlights the medicinal chemistry prospective emphasising about the designing strategies, docking studies, biological evaluation, selectivity and structural activity relationship of N-heterocyclic compounds. Our review will support the medicinal chemists in direction for the development of novel N-heterocyclic based EGFR TKIs.

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Section: Importance Of Nitrogen Containing Heterocyclic Compound As E...mentioning

confidence: 99%

Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships

Pal¹,

Teli²,

Matada³

et al. 2023

ChemistrySelect

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“…These reported compounds were docked by Molegro Virtual Docker (MVD) software using a similar protocol as mentioned by Teli et al. [72] Plants scores and MolDock scores of Src kinase protein were described in Table 2. The hydrogen bond interactions of all docked molecules were mentioned in their respective section.…”

Section: Molecular Docking Studymentioning

confidence: 99%

Medicinal Chemistry Perspectives on Recent Advances in Src Kinase Inhibitors as a Potential Target for the Development of Anticancer Agents: Biological Profile, Selectivity, Structure‐Activity Relationship

Teli¹,

Pal²,

Maji³

et al. 2023

Chemistry & Biodiversity

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The physiological Src proto‐oncogene is a protein tyrosine kinase receptor that served as the essential signalling pathway in different types of cancer. The etiology of cancer involved various signalling pathways and Src signalling pathways are also involved in those clusters. Although the dysregulation of Src kinase resulted in cancer being discovered in the late 19th century it is still considered a cult pathway because it is not much explored by different medicinal chemists and oncologists. In this review, we have elaborated about the structure and activation of Src kinase, as well as the development of Src kinase inhibitors. Our group also provided a comprehensive overview of Src inhibitors throughout the last two decades, including their biological activity, structure‐activity relationship, and Src kinase selectivity. The Src binding pocket has been investigated in detail to better comprehend the interaction of Src inhibitors with amino acid residues. We have strengthened the literature with our contribution in terms of molecular docking and ADMET studies of top compounds. We hope that the current analysis will be a useful resource for researchers and provide glimpse of direction toward the design and development of more specific, selective, and potent Src kinase inhibitors.

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“… 5 Thiazolinones, on the other hand, are recognized to induce a myriad of anticancer effects. 6 , 7 , 8 , 9 , 10 , 11 We have previously developed a group of compounds with promising anti-cancer activity by combining 5-aminosalicylic acid (5-ASA) with 4-thiazolinone. 12 Screening and testing the activity of such compounds on cancer and normal cells identified four compounds with good anti-cancer activity and some degree of selectivity toward cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

Ramadan,

Saber-Ayad,

Saleh

et al. 2024

iScience

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Exploring the Potential of Substituted 4-Thiazolidinone Derivatives in the Treatment of Breast Cancer: Synthesis, Biological Screening and In Silico Studies

Cited by 5 publications

References 45 publications

Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships

Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships

Medicinal Chemistry Perspectives on Recent Advances in Src Kinase Inhibitors as a Potential Target for the Development of Anticancer Agents: Biological Profile, Selectivity, Structure‐Activity Relationship

Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

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