Exploring the potential of silymarin-loaded nanovesicles as an effective drug delivery system for cancer therapy: in vivo, in vitro, and in silico experiments

Hajinezhad, Mohammad Reza; Roostaee, Maryam; Nikfarjam, Zahra; Rastegar, Sanaz; Sargazi, Ghasem; Barani, Mahmood; Sargazi, Saman

doi:10.1007/s00210-024-03099-3

Naunyn-Schmiedeberg's Arch Pharmacol

2024

DOI: 10.1007/s00210-024-03099-3

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Exploring the potential of silymarin-loaded nanovesicles as an effective drug delivery system for cancer therapy: in vivo, in vitro, and in silico experiments

Mohammad Reza Hajinezhad,

Maryam Roostaee,

Zahra Nikfarjam

et al.

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2024

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Cited by 3 publications

References 64 publications

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Enhancing Drug Delivery With Electrospun Biopolymer Nanofibers

Shastri,

Varma,

Kandasubramanian

2024

Biomedical Materials & Devices

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Enhancing Drug Delivery With Electrospun Biopolymer Nanofibers

Shastri,

Varma,

Kandasubramanian

2024

Biomedical Materials & Devices

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Development, characterization, and evaluation of withaferin-A and artesunate-loaded pH-responsive acetal-dextran polymeric nanoparticles for the management of malaria

Pradhan,

Biswasroy,

Ramchandani

et al. 2024

International Journal of Biological Macromolecules

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Silybin-Functionalized PCL Electrospun Fibrous Membranes for Potential Pharmaceutical and Biomedical Applications

Spartali,

Psarra,

Marras

et al. 2024

Polymers

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Silybin is a natural flavonolignan with potential anticancer, antioxidant, and hepatoprotective properties. In the present study, various loadings of silybin (1, 3, and 5 wt%) were encapsulated in poly-ε-caprolactone (PCL) fibers by electrospinning, in order to produce new pharmaceutical composites with improved bioactive and drug delivery properties. The morphological characteristics of the composite fibrous structures were evaluated by scanning electron microscopy (SEM), and the encapsulation efficiency and the release rate of silybin were quantified using a UV-Vis spectrophotometer. The analysis of the membranes’ thermal behavior by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) revealed the existence of interaction between PCL and silybin. An investigation of the cytocompatibility of the composite membranes revealed that normal cells displayed an unimpeded proliferation in the respective silybin concentrations; however, tumor cell growth demonstrated a dose-dependent inhibition. Furthermore, an effective antioxidant activity against hydrogen peroxide-induced oxidative stress in HEK-293 cells was observed for the prepared electrospun fibrous mats.

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Exploring the potential of silymarin-loaded nanovesicles as an effective drug delivery system for cancer therapy: in vivo, in vitro, and in silico experiments

Cited by 3 publications

References 64 publications

Enhancing Drug Delivery With Electrospun Biopolymer Nanofibers

Enhancing Drug Delivery With Electrospun Biopolymer Nanofibers

Development, characterization, and evaluation of withaferin-A and artesunate-loaded pH-responsive acetal-dextran polymeric nanoparticles for the management of malaria

Silybin-Functionalized PCL Electrospun Fibrous Membranes for Potential Pharmaceutical and Biomedical Applications

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