Exploring the Potential of Moi Gum for Diverse Applications: A Review

Mate, Ch. Jamkhokai; Mishra, Sumit

doi:10.1007/s10924-020-01709-8

Cited by 11 publications

(3 citation statements)

References 47 publications

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“…[30][31][32] Semi-IPN microspheres of carboxymethylcellulose-gelatin have recently been reported for regulated release of ketorolac tromethamine. 33,34 The hydrophilic arabinogalactan isolated from Lannea coromandelica (Houtt) tree belonging to the family Anacardiaceae, 35 is popularly known as Moi gum. It has been identified as a neutral polysaccharide constituted in a 4:1 ratio of d-galactose and l-arabinose.…”

Section: Introductionmentioning

confidence: 99%

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Inorganic metal salts as additives in the design of cellulose/arabinogalactan hydrogels for prolonged delivery of simvastatin in simulated bio‐fluids

Agrawal,

Yadav,

Patel

et al. 2023

Vinyl Additive Technology

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In this study, carboxymethylcellulose and arabinogalactan were used to create an interpenetrating network (IPN) hydrogel system in the presence of AlCl3 alone or in combination with ZnSO4 salts. Ionotropic gelation caused the polymer sol droplets to transform into hydrogel particles in the presence of salts. The impact of salts on hydrogel properties was evaluated in terms of morphology, drug entrapment efficiency, swelling, and drug release kinetics. The cellulose IPN hydrogel particles containing 50% arabinogalactan looked spherical with evidence of surface folding when treated with AlCl3. Surface folding was reduced by an additional treatment with ZnSO4. Following treatment of the IPN particles with dual salts, a maximum drug entrapment efficiency of 88.77% was obtained. Surface erosion, as seen with aluminum‐IPN hydrogel particles, was minimized with the use of mixed salts as gelation medium. Furthermore, the use of mixed salts allowed the hydrogel particles to swell and consistently release simvastatin in simulated gastrointestinal fluids for up to 9 h. Thermal and x‐ray analyses revealed that the crystallinity of the drug reduced considerably after entrapment in the IPN hydrogel matrix. The infrared spectra analysis did not indicate any evidence of drug polymer interaction. The release of drug from the IPN hydrogel particles followed non‐Fickian diffusion mechanism. The dual metallic salts were found to be effective in creating physically stable cellulose‐arabinogalactan IPN hydrogel particles for sustained release of simvastatin in a varying pH environment of gastrointestinal tract.Highlights Dual inorganic salts allowed synthesis of cellulose/arabinogalactan hydrogel Additional use of ZnSO4 improved surface morphology of hydrogel particles Compatible environment of hydrogels allowed more than 88% drug entrapment Concentration of neutral arabinogalactan was crucial in dictating drug release Mixed salts controlled swelling and release of simvastatin from hydrogels

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Section: Introductionmentioning

confidence: 99%

“…The hydrophilic arabinogalactan isolated from Lannea coromandelica (Houtt) tree belonging to the family Anacardiaceae, 35 is popularly known as Moi gum. It has been identified as a neutral polysaccharide constituted in a 4:1 ratio of d‐galactose and l‐arabinose 36 .…”

Section: Introductionmentioning

confidence: 99%

Inorganic metal salts as additives in the design of cellulose/arabinogalactan hydrogels for prolonged delivery of simvastatin in simulated bio‐fluids

Agrawal,

Yadav,

Patel

et al. 2023

Vinyl Additive Technology

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“…[41] It is composed of 1, 3-linked β-D-galactopyranosyl units (main chain) with α-L-arabinofuranosyl units joined to the main chain by 1, 6-linkage. [42] It is known to be a neutral polysaccharide composed of D-galactose and L-arabinose in the 4:1 ratio. [43] Moi gum has been investigated as drug delivery carriers in the form of matrix tablets, [44][45][46][47][48] microspheres, [49] table binders.…”

Section: Introductionmentioning

confidence: 99%

Ascendancy of pH‐irresponsive Moi gum in the design of modified xanthan gum semi‐interpenetrating network hydrogels for monitoring diabetes

Patel

Moorthy

Maiti

2022

Polymer Engineering & Sci

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This investigation used Moi gum to develop semi-interpenetrating polymer network (IPN) hydrogel particles with carboxymethyl xanthan gum in aqueous environment using aluminum chloride as crosslinker. The semi-IPN hydrogel systems had >90% of drug entrapment efficiency. Increase in Moi gum concentration from 33.33% to 66.66% reduced swelling of semi-IPN hydrogel particles by 17.6% and 23.3% in pH 1.2 and pH 6.8, respectively in 2 h. The semi-IPN hydrogel particles made up of 66.66% Moi gum released 94.8% of drug in 8 h. The modified xanthan gum alone however released about 98% drug in 3 h in simulated gastrointestinal pH. Irrespective of pH, the drug release followed an anomalous diffusion mechanism. FTIR analysis did not reveal any drugpolymer interaction. The thermal and x-ray diffraction investigations suggested amorphous state of drug in semi-IPN hydrogel system. Moreover, the hydrogel systems demonstrated more than 90% Caco-2 cell viability which supported the non-toxic nature of the hydrogel system. Preclinical experiments on male albino rats showed that the semi-IPN hydrogel systems could allow monitoring of anti-diabetic efficacy over 8 h. Overall, a suitable combination of negatively charged and neutral polysaccharides appeared promising in developing semi-IPN hydrogel particles, which could tailor the drug delivery performance, especially the drug release process and preclinical anti-diabetic activity.

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