Exploring the potential of Brazilian Amazonian scorpion venoms: A comprehensive review of research from 2001 to 2021

Ramanan da Cruz, Joel; Bulet, Philippe; Mendonça de Moraes, Cléria

doi:10.1016/j.toxcx.2023.100182

Toxicon: X

2024

DOI: 10.1016/j.toxcx.2023.100182

|View full text |Cite

Exploring the potential of Brazilian Amazonian scorpion venoms: A comprehensive review of research from 2001 to 2021

Joel Ramanan da Cruz,

Philippe Bulet,

Cléria Mendonça de Moraes

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

In vitro activity of Tityus metuendus and Brotheas amazonicus scorpion venoms against Plasmodium falciparum FRC3

Procópio,

Pereira,

Martins

et al. 2024

IJMMTD

View full text Add to dashboard Cite

Scorpion venoms contain different classes of molecules with possible pharmacological activities, making them sources of bioactive molecules for the development of new drugs against infections caused by pathogens, such as malaria, a disease caused by protozoa of the genus Plasmodium. Malaria faces challenges in its control due to pathogen resistance to available antimalarials. In this study, we evaluated the venom activity of the Amazonian scorpions and against FRC3, the analysis was performed by flow cytometry. At the analyzed concentrations, we found that the crude venom of had an average inhibition of 87% at the concentration of 100 µg/mL, above that obtained with the drug (quinine), which had mean inhibition of 84% against FCR3. Regarding the venom of , lower activity was observed in comparison with the inhibition potential of the venom and the standard drug, venom showed low toxicity against the human fibroblast MRC5. Because peptides and toxins from scorpion venom are related to biological functions, they can be used in the design of new therapeutic agents, with venom being a possible source of molecules for the development of antimalarial drugs.

show abstract

In vitro activity of Tityus metuendus and Brotheas amazonicus scorpion venoms against Plasmodium falciparum FRC3

Procópio,

Pereira,

Martins

et al. 2024

IJMMTD

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Exploring the potential of Brazilian Amazonian scorpion venoms: A comprehensive review of research from 2001 to 2021

Cited by 1 publication

References 43 publications

In vitro activity of Tityus metuendus and Brotheas amazonicus scorpion venoms against Plasmodium falciparum FRC3

In vitro activity of Tityus metuendus and Brotheas amazonicus scorpion venoms against Plasmodium falciparum FRC3

Contact Info

Product

Resources

About