Exploring the Potential of Anthraquinone‐Based Hybrids for Identifying a Novel Generation of Antagonists for the Smoothened Receptor in HH‐Dependent Tumour
Deborah Quaglio,
Paola Infante,
Silvia Cammarone
et al.
Abstract:Natural products (NPs) are highly profitable pharmacological tools due to their chemical diversity and ability to modulate biological systems. Accessing new chemical entities while retaining the biological relevance of natural chemotypes is a fundamental goal in the design of novel bioactive compounds. Notably, NPs have played a crucial role in understanding Hedgehog (HH) signalling and its pharmacological modulation in anticancer therapy. However, HH antagonists developed so far have shown several limitations… Show more
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