Exploring the Potential of a Meditation-Based Liver Cancer Classification Signature for Adjunctive Therapy

Abstract

Mindfulness meditation, as a non-therapeutic approach, holds immense significance in alleviating stress and regulating mental well-being. However, its utilization in disease treatment and clinical contexts remains largely unexplored. In light of cutting-edge research involving RNA sequencing data, we have successfully developed a gene signature, derived from differential gene expression during four distinct stages of meditation, to effectively classify patients with liver cancer. Our findings indicate that liver cancer patients can be stratified into two subtypes characterized by varying prognoses, immune microenvironments, tumor mutation burdens, and drug sensitivities. This tailored classification approach not only enables personalized chemotherapy strategies for liver cancer patients but also integrates meditation as a complementary intervention, significantly mitigating the adverse effects associated with chemotherapy.