Exploring the potential function of trace elements in human health: a therapeutic perspective

Islam, Md. Rezaul; Akash, Shopnil; Jony, Maruf Hossain; Alam, Md. Noor; Nowrin, Feana Tasmim; Rahman, Md. Mominur; Rauf, Abdur; Thiruvengadam, Muthu

doi:10.1007/s11010-022-04638-3

Cited by 44 publications

(25 citation statements)

References 228 publications

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“…[28] Copper is involved in the formation of red blood cells, maintaining the immune system, and aiding in the absorption of iron. [29] Chromium is essential for carbohydrate metabolism and insulin function. [30] These findings support previous studies that have highlighted the use of anise as a stimulant and appetizer for vital organs such as the lungs, liver, heart, and brain.…”

Section: Discussionmentioning

confidence: 99%

Nutritional Value and in vitro Antigiardial Activity of Anise (Pimpinella anisum L.) Seeds

Alrasheid,

Kabbashi,

Ali

et al. 2024

Chemistry & Biodiversity

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The present study focused on evaluating the proximate analysis, mineral composition, and in vitro anti‐giardial activity of Pimpinella anisum seed extracts, which are aromatic plants with a long history of usage in folk and conventional medicine, as well as pharmaceutical manufacturing. Standard methods were used to determine the proximate analysis of the powdered plant sample, including dry matter, ash, fat, protein, fiber, and carbohydrates. The mineral contents of Pimpinella anisum seed were analyzed using Inductively Coupled Plasma Mass Spectrometry (ICP‐MS), revealing that the plant has a high fiber content (42.62%) followed by carbohydrates (38.79%). The seeds were also found to be a rich source of minerals, with notable amounts of Rubidium, Magnesium, and Calcium. The extracts showed a high mortality percentage compared to Metronidazole, with the chloroform extract exhibiting higher anti‐giardial activity (78.71%) than the ethanolic extract (75.29%) at a concentration of 500 ppm. These findings support the traditional use of Anise in treating gastrointestinal issues and as a natural supplement. Further studies are needed to isolate the active ingredients and understand their mechanism of action.

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Section: Discussionmentioning

confidence: 99%

Nutritional Value and in vitro Antigiardial Activity of Anise (Pimpinella anisum L.) Seeds

Alrasheid,

Kabbashi,

Ali

et al. 2024

Chemistry & Biodiversity

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“…It has been widely believed that zinc participates in various physiological and pathological processes, including virus infection [ 10 , 50 ]. Studies have shown that zinc has the potential to inhibit influenza virus infections by multiple possible mechanisms [ 51 , 52 ].…”

Section: Zinc Show Potential Anti-influenza Activity By Decreasing Ha...mentioning

confidence: 99%

“…Trace elements occupy less than a ten-thousandth of total body elements, but they are extremely indispensable for human life, including growth, development, and metabolism [ 9 , 10 ]. A deficiency of trace elements is closely related to various diseases [ 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Negligible Role of Trace Elements in Influenza Virus Infection

Wang

Zhao

et al. 2023

Metabolites

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Influenza virus has continuously spread around the globe for more than 100 years since the first influenza epidemic in 1918. The rapid and unpredictable gene variation of the influenza virus could possibly bring about another pandemic in future, which might threaten to overwhelm us without adequate preparation. Consequently, it is extremely urgent to identify effective broad-spectrum antiviral treatments for a variety of influenza virus variants. As essential body components, trace elements are great potential candidates with an as yet poorly understood ability to protect the host from influenza infection. Herein, we have summarized the present state of knowledge concerning the function of trace elements in influenza virus replication along with an analysis of their potential molecular mechanisms. Modulation of host immune responses to the influenza virus is one of the most common modes to achieve the anti-influenza activity of trace elements, such as selenium and zinc. Simultaneously, some antioxidant and antiviral signal pathways can be altered with the participation of trace elements. More interestingly, some micro-elements including selenium, zinc, copper and manganese, directly target viral proteins and regulate their stability and activity to influence the life cycle of the influenza virus. Further verification of the antiviral effect and the mechanism will promote the application of trace elements as adjuvants in the clinic.

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“…8,9 The key to the design and preparation of bioactive complexes is the choice of metal centers and suitable organic ligands. Zinc, which is the second most abundant trace metal found in the biological system, 12,13 is an essential trace element that contributes significantly to the overall well-being of individuals. 10,11 Pyridine derivatives are one of the heterocycles and have important pharmacological activities such as anticancer 14 and antibacterial.…”

Section: Introductionmentioning

confidence: 99%

Trifluoromethyl-pyridine carboxylic acid Zn(ii) complexes: isomeric effects on coordination and biological activity

Zhu,

Yang,

et al. 2024

New J. Chem.

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Exploring the potential function of trace elements in human health: a therapeutic perspective

Cited by 44 publications

References 228 publications

Nutritional Value and in vitro Antigiardial Activity of Anise (Pimpinella anisum L.) Seeds

Nutritional Value and in vitro Antigiardial Activity of Anise (Pimpinella anisum L.) Seeds

Non-Negligible Role of Trace Elements in Influenza Virus Infection

Trifluoromethyl-pyridine carboxylic acid Zn(ii) complexes: isomeric effects on coordination and biological activity

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