Exploring the possibility of predicting long‐term oxidative stability in prototype skincare formulations using various lipid oxidation initiators

Abstract

OBJECTIVE: The purpose of this study was to identify an effective lipid oxidation initiator which could predict, within 1 month, the long-term oxidative stability of a prototype skincare formulation. The main purpose was to find a potential initiator not to assess oxidation stability of the formulations. METHODS: Four initiators (below) were examined in three steps: R ESULTATS: Dans l'oxygraphe, les syst emes initiateurs FeCl 2 / H 2 O 2 et FeCl 3 /acide ascorbique etaient de bons acc el erateurs de la consommation en oxyg ene. L'addition de FeCl 2 /H 2 O 2 aux prototypes de formulations n'a pas eu d'impact sur la stabilit e physique. Cependant, l'addition de FeCl 3 /acide ascorbique aux prototypes de formulations a entraîn e une s eparation des phases et le syst eme FeCl 3 /acide ascorbique a donc et e jug e inutilisable. De plus, l'addition d'AAPH ou d'AMVN a entraîn e une augmentation et une diminution de la viscosit e, respectivement.