Abstract:Coordination chemistry is a major
component of the undergraduate
inorganic chemistry curriculum, and yet, the presentation of the material
can be cumbersome due to the limitations of the course typically being
taught in one semester. Also, because of the large scope of this branch
of chemistry encompassing all of the elements, the course design has
not been standardized. These factors result in some important coordination
chemistry themes being given insufficient development. Herein, we
propose a novel activit… Show more
“…Ceruloplasmin is the main Cu transporter in blood and serum albumin also contributes but to a smaller extent [69][70][71]. Competitive biomolecular metal binding greatly influences blood metal speciation [72][73][74][75] as does metal hydrolysis for hard Lewis acidic metals like Ga(III).…”
Section: Challenging the Perception Of Structural Requirements For Metalated-stf Endocytotic Uptake Into Cellsmentioning
Serum transferrin (sTf) plays a pivotal role in regulating iron biodistribution and homeostasis within the body. The molecular details of sTf Fe(III) binding blood transport, and cellular delivery through transferrin receptor-mediated endocytosis are generally well-understood. Emerging interest exists in exploring sTf complexation of nonferric metals as it facilitates the therapeutic potential and toxicity of several of them. This review explores recent X-ray structural and physiologically relevant metal speciation studies to understand how sTf partakes in the bioactivity of key non-redox active hard Lewis acidic metals. It challenges preconceived notions of sTf structure function correlations that were based exclusively on the Fe(III) model by revealing distinct coordination modalities that nonferric metal ions can adopt and different modes of binding to metal-free and Fe(III)-bound sTf that can directly influence how they enter into cells and, ultimately, how they may impact human health. This knowledge informs on biomedical strategies to engineer sTf as a delivery vehicle for metal-based diagnostic and therapeutic agents in the cancer field. It is the intention of this work to open new avenues for characterizing the functionality and medical utility of nonferric-bound sTf and to expand the significance of this protein in the context of bioinorganic chemistry.
“…Ceruloplasmin is the main Cu transporter in blood and serum albumin also contributes but to a smaller extent [69][70][71]. Competitive biomolecular metal binding greatly influences blood metal speciation [72][73][74][75] as does metal hydrolysis for hard Lewis acidic metals like Ga(III).…”
Section: Challenging the Perception Of Structural Requirements For Metalated-stf Endocytotic Uptake Into Cellsmentioning
Serum transferrin (sTf) plays a pivotal role in regulating iron biodistribution and homeostasis within the body. The molecular details of sTf Fe(III) binding blood transport, and cellular delivery through transferrin receptor-mediated endocytosis are generally well-understood. Emerging interest exists in exploring sTf complexation of nonferric metals as it facilitates the therapeutic potential and toxicity of several of them. This review explores recent X-ray structural and physiologically relevant metal speciation studies to understand how sTf partakes in the bioactivity of key non-redox active hard Lewis acidic metals. It challenges preconceived notions of sTf structure function correlations that were based exclusively on the Fe(III) model by revealing distinct coordination modalities that nonferric metal ions can adopt and different modes of binding to metal-free and Fe(III)-bound sTf that can directly influence how they enter into cells and, ultimately, how they may impact human health. This knowledge informs on biomedical strategies to engineer sTf as a delivery vehicle for metal-based diagnostic and therapeutic agents in the cancer field. It is the intention of this work to open new avenues for characterizing the functionality and medical utility of nonferric-bound sTf and to expand the significance of this protein in the context of bioinorganic chemistry.
“…42 Additionally, chemometric methods, including multivariate statistics, have been employed to quantify active substances in mixtures using spectrophotometric data, demonstrating their versatility in organic pollutant determination. 43,44 Furthermore, the combination of spectroscopic methods with chemometric tools, such as multivariate curve resolution (MCR) and partial least squares regression, has been shown to be effective in solving the mixture analysis problem, providing chemically meaningful models of pure contributions from complex spectroscopic data. 45 This approach has been particularly valuable in the analysis of trace metals in environmental matrices, contributing to the accurate determination of organic pollutants in environmental samples.…”
Section: Chemometric Approaches For Data Enhancementmentioning
The review paper explores new experimental and chemometric methods in spectroscopy for detecting organic pollutants in natural waters, aiming to improve sustainability and monitoring accuracy.
“…[1][2][3] Deeply colored representative complexes from this block are often used as examples in chemical education for their vibrant illustration of photophysical transitions. 4 Despite a rich history of study, the incorporation of such transitions into catalytic manifolds has thus far been limited. Recent advances in photoredox and photocatalysis have ignited renewed interest in utilizing light energy to enable organic transformations.…”
The absorption of light by photosensitizers has been shown to offer novel reactive pathways through electronic excited state intermediates, complementing ground-state mechanisms. Such strategies have been applied in both photocatalysis and photoredox catalysis, driven by generating reactive intermediates from their long-lived excited states. One developing area is photoinduced ligand-to-metal charge transfer (LMCT) catalysis, in which coordination of a ligand to a metal center and subsequent excitation with light results in the formation of a reactive radical and a reduced metal center. This mini review concerns the foundations and recent developments on ligand-to-metal charge transfer in transition-metal catalysis, focusing on the organic transformations made possible through this mechanism.1 Introduction2 Iron3 Cobalt4 Nickel5 Copper6 Future Outlook and Conclusion
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