Exploring the Mumps Virus Glycoproteins: A Review

Abstract

The resurgence of mumps in vaccinated adult populations has raised concerns about possible waning vaccine immunity or a potential lack of protection to the circulating strain. A number of individual studies have investigated if there are amino acid variations between the circulating wild-type strains and vaccine strains. In these studies, the HN and F mumps surface glycoproteins have been of interest, because of their role in viral infection, and because the HN protein is the target of neutralizing antibodies. Here, we summarize the single nucleotide variants and their potential effect that have been identified between mumps genotypes in the HN and F proteins.

Investigating Local Patterns of Mumps Virus Circulation, Using a Combination of Molecular Tools

“…The reappearance of MuV, during recent years in countries with high vaccination coverage is a matter of concern, since it suggests a suboptimal effectiveness of current vaccines [2,6], which do not allow the elimination of viral circulation, although they provide a substantial reduction in complications [7]. Proposed explanations for this reduced efficacy of the vaccine include waning immunity [2,8] reduced cross-reactivity between genotypes [9,10] or between the circulating MuV and the vaccine strains, due to an antigenic drift from the time when the vaccine strains were isolated [11,12].…”