Exploring the molecular mechanism of Lycium barbarum L. against breast cancer based on network pharmacology

Hu, Zhiyuan; Ning, Mingliang; Qin, Shaojie; Yu, Kangkang

doi:10.1016/j.jff.2023.105545

Cited by 4 publications

(1 citation statement)

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“…Hu et al utilized these techniques to investigate the therapeutic effects of wolfberry on breast cancer. They screened active components and their targets, constructed ingredient–target–disease and protein–protein interaction networks, and performed GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analyses [ 157 ].…”

Section: Antitumor Activity Of Lycium Barbarummentioning

confidence: 99%

Antitumor Mechanisms of Lycium barbarum Fruit: An Overview of In Vitro and In Vivo Potential

Miranda,

Vestuto,

Amodio

et al. 2024

Life

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Lycium barbarum, known as goji berry or wolfberry, is a fruit long associated with health benefits, showing a plethora of effects ranging from antioxidant, anticancer, anti-inflammatory, and immunomodulatory effects. Its potential is attributed to the significant presence of polysaccharides, glycopeptides, polyphenols, flavonoids, carotenoids, and their derivatives. These compounds effectively counteract the action of free radicals, positively influencing cellular balance and intracellular signaling, contributing to overall cell health and function acting on multiple molecular pathways. Several fractions extracted from goji berries demonstrate antitumor properties, particularly effective against breast cancer, without showing cytotoxic effects on normal human cells. Hence, the review explored the fundamental traits of bioactive elements in Lycium barbarum and their potential in cancer treatment and, specifically, breast cancer. It focused on elucidating wolfberry’s influenced biochemical pathways, its synergism with anticancer drugs, and its potential to alleviate the side effects associated with existing cancer treatments.

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Section: Antitumor Activity Of Lycium Barbarummentioning

confidence: 99%