Exploring the molecular landscape of multicomponent crystals formed by naproxen drug and acridines

Abstract

The co-crystallization of active pharmaceutical ingredient naproxen with some acridines (acridine, 9-aminoacridine, 6,9-diamino-2-ethoxyacridine) has been explored, as well as the conditions under which the crystallization can be carried out have...

Small-Angle X-ray Scattering (SAXS) Used for the Identification of Nicomorphine Polymorphic Changes at the Early Stage to Avoid Varied Stability and Possible Side Effects

“…In addition, this also leads us to strengthen and support this area of analytics, since few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns. Thus, more commitment is necessary by regulatory and quality control authorities to monitor polymorphism for all commercial drugs and not only for research and development [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. The stability of drugs is always an important issue and aging or instability are for many products still not sufficiently investigated at the nanoscale, where changes in polymorphism with time can occur without their timely identification [ 26 ].…”

“…Therefore, the message of this paper is simply to show that the use of additional non-standard methods with extended resolution scale for structure quality (such as SAXS) can be very useful for detecting such objections in the drug and thereby avoiding possible side effects of the drug in human body. The fact is that SAXS is also used like WAXS, XRD or other methods [ 17 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ] in the study of polymorphism [ 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ,…”

Structural insight and in silico prediction of the pharmacokinetic parameters and toxicity of alkaline earth metal compounds strontium and barium with the non-steroidal anti-inflammatory drug nimesulide

“…For the reasons above, in this communication, as a continuation of our recent studies on multicomponent crystals involving non-steroidal anti-inflammatory drugs, 28,29,31,32 we report the synthesis, structural characterization and in silico prediction of the pharmacokinetic parameters and toxicity of alkaline earth metal complexes strontium and barium with nimesulide.…”

“…23 There are also only several structures containing the non-steroidal anti-inflammatory drug nimesulide 24 (IUPAC name: 4-nitro-2-phenoxymethanesulfonanilide), [25][26][27][28][29] including five structures of nimesulide-silver organometallic complexes. 30 For the reasons above, in this communication, as a continuation of our recent studies on multicomponent crystals involving non-steroidal anti-inflammatory drugs, 28,29,31,32 we report the synthesis, structural characterization and in silico prediction of the pharmacokinetic parameters and toxicity of alkaline earth metal complexes strontium and barium with nimesulide.…”

Crystallization from solution versus mechanochemistry to obtain double-drug multicomponent crystals of ethacridine with salicylic/acetylsalicylic acids

“…1 ), drugs with complementary antiseptic properties are described. Reactivity of these APIs in different environments was explored to obtain the possible compounds, stable at different hydration degrees, exploiting previously 19 developed protocols. The role of water in driving the crystallization was explored applying the solution, LAG and dry grinding approaches to the couples of reactants (Fig.…”