Exploring the Molecular Interaction of PCOS and Endometrial Carcinoma through Novel Hyperparameter-Optimized Ensemble Clustering Approaches

Abstract

Polycystic ovary syndrome (PCOS) and endometrial carcinoma (EC) are gynecological conditions that have attracted significant attention due to the higher prevalence of EC in patients with PCOS. Even with this proven association, little is known about the complex molecular pathways that connect PCOS to an increased risk of EC. In order to address this, our study presents two main innovations. To provide a solid basis for our analysis, we have first created a dataset of genes linked to EC and PCOS. Second, we start by building fixed-size ensembles, and then we refine the configuration of a single clustering algorithm within the ensemble at each step of the hyperparameter optimization process. This optimization evaluates the potential performance of the ensemble as a whole, taking into consideration the interactions between each algorithm. All the models in the ensemble are individually optimized with the suitable hyperparameter optimization method, which allows us to tailor the strategy to the model’s needs. Our approach aims to improve the ensemble’s performance, significantly enhancing the accuracy and robustness of clustering outcomes. Through this approach, we aim to enhance our understanding of PCOS and EC, potentially leading to diagnostic and treatment breakthroughs.