Exploring the metastasis-related biomarker and carcinogenic mechanism in liver cancer based on single cell technology

Zheng, Qiuxiang; Lu, Cuiping; Yu, Lian; Zhan, Ying; Chen, Zhiyong

doi:10.1016/j.heliyon.2024.e27473

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e27473

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Exploring the metastasis-related biomarker and carcinogenic mechanism in liver cancer based on single cell technology

Qiuxiang Zheng,

Cuiping Lu,

Lian Yu

et al.

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2024

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Cited by 2 publications

References 88 publications

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Pancancer analysis of NDUFA4L2 with focused role in tumor progression and metastasis of colon adenocarcinoma

Zhou,

Sun,

Zhou

et al. 2024

Med Oncol

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Pancancer analysis of NDUFA4L2 with focused role in tumor progression and metastasis of colon adenocarcinoma

Zhou,

Sun,

Zhou

et al. 2024

Med Oncol

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Mendelian randomization analysis identified potential genes pleiotropically associated with gout

Wang,

Chen,

Yao

et al. 2024

Front. Genet.

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BackgroundThis study aims to prioritize genes potentially involved in multifactorial or causal relationships with gout.MethodsUsing the Summary Data-based Mendelian Randomization (SMR) approach, this research analyzed expression quantitative trait loci (eQTL) data from blood and renal tissues and genome-wide association study (GWAS) data related to gout. It sought to identify genetic loci potentially involved in gout. Heterogeneity testing was conducted with the HEIDI test, and results were adjusted for the False Discovery Rate (FDR). Blood cis-eQTL data were sourced from the eQTLGen Consortium’s summary-level data, and renal tissue data came from the V8 release of the GTEx eQTL summary data. Gout GWAS data was sourced from the FinnGen Documentation of the R10 release.ResultSMR analysis identified 14 gene probes in the eQTLGen blood summary-level data significantly associated with gout. The top five ranked genes are: ENSG00000169231 (labeled THBS3, PSMR = 4.16 × 10−13), ENSG00000231064 (labeled THBS3-AS1, PSMR = 1.88 × 10−8), ENSG00000163463 (labeled KRTCAP2, PSMR = 3.88 × 10−6), ENSG00000172977 (labeled KAT5, PSMR = 1.70 × 10−5), and ENSG00000161395 (labeled PGAP3, PSMR = 3.24 × 10−5). Notably, increased expression of KRTCAP2 and PGAP3 is associated with an increased risk of gout, whereas increased expression of THBS3, THBS3-AS1, and KAT5 is associated with a reduced gout risk. No significant gene associations with gout were observed in renal tissue, likely due to the limited sample size of kidney tissue.ConclusionOur findings have highlighted several genes potentially involved in the pathogenesis of gout. These results offer valuable insights into the mechanisms of gout and identify potential therapeutic targets for its treatment.

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Exploring the metastasis-related biomarker and carcinogenic mechanism in liver cancer based on single cell technology

Cited by 2 publications

References 88 publications

Pancancer analysis of NDUFA4L2 with focused role in tumor progression and metastasis of colon adenocarcinoma

Pancancer analysis of NDUFA4L2 with focused role in tumor progression and metastasis of colon adenocarcinoma

Mendelian randomization analysis identified potential genes pleiotropically associated with gout

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