Exploring the membrane fluidity of phenyl boronic acid functionalized polymersomes using the FRAP technique and their application in the pH-sensitive release of curcumin

Damera, Deepthi Priyanka; Nag, Amit

doi:10.1039/d2nj01330d

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…pH-triggered particles are designed with the aim of inducing a change in hydrophilicity/hydrophobicity upon protonation/deprotonation equilibrium in the particle. Previously reported pH–responsive systems include esters [ 113 ], acetals [ 114 ], boronic acids [ 115 ], hydrazones [ 116 ], imines [ 117 ] and functional groups. To ensure drug release, the cleavage of acid/base-sensitive bonds must induce a significant change in permeability, which is often achieved via structural fragmentation, depolymerisation or polarity change.…”

Section: Physicochemical Triggers For Controlled Drug Release From Po...mentioning

confidence: 99%

Design of Tailor-Made Biopolymer-Based Capsules for Biological Application by Combining Porous Particles and Polysaccharide Assembly

2023

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Various approaches have been described in the literature to demonstrate the possibility of designing biopolymer particles with well-defined characteristics, such as size, chemical composition or mechanical properties. From a biological point of view, the properties of particle have been related to their biodistribution and bioavailability. Among the reported core–shell nanoparticles, biopolymer-based capsules can be used as a versatile platform for drug delivery purposes. Among the known biopolymers, the present review focuses on polysaccharide-based capsules. We only report on biopolyelectrolyte capsules fabricated by combining porous particles as a template and using the layer-by-layer technique. The review focuses on the major steps of the capsule design, i.e., the fabrication and subsequent use of the sacrificial porous template, multilayer coating with polysaccharides, the removal of the porous template to obtain the capsules, capsule characterisation and the application of capsules in the biomedical field. In the last part, selected examples are presented to evidence the major benefits of using polysaccharide-based capsules for biological purposes.

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Section: Physicochemical Triggers For Controlled Drug Release From Po...mentioning

confidence: 99%

Design of Tailor-Made Biopolymer-Based Capsules for Biological Application by Combining Porous Particles and Polysaccharide Assembly

2023

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Polymersomes-based curcumin delivery as cancer therapeutics

Castro,

Barbosa,

Greaves

et al. 2024

Curcumin-Based Nanomedicines as Cancer Therapeutics

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Exploring the membrane fluidity of phenyl boronic acid functionalized polymersomes using the FRAP technique and their application in the pH-sensitive release of curcumin

Abstract: Although functionalization of the Drug Delivery Systems (DDS) for targeting tumor cells have been reported earlier, but the changes in the membrane fluidity due to functionalization is not well studied....

Cited by 2 publications

References 49 publications

Design of Tailor-Made Biopolymer-Based Capsules for Biological Application by Combining Porous Particles and Polysaccharide Assembly

Design of Tailor-Made Biopolymer-Based Capsules for Biological Application by Combining Porous Particles and Polysaccharide Assembly

Polymersomes-based curcumin delivery as cancer therapeutics

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