Exploring the Mechanism of Zanthoxylum Bungeanum Maxim in the Treatment of Osteoarthritis Based on Network Pharmacology, Molecular Docking and Molecular Dynamics Simulation
Abstract:Zanthoxylum bungeanum Maxim (ZBM) is a traditional Chinese seasoning, and is often used as a Chinese herbal medicine in treating osteoarthritis (OA) and other diseases, but its active ingredients and pharmacological mechanisms are still unclear. We used network pharmacology, molecular docking, and molecular dynamics simulation (MDS) to explore the potential mechanisms of ZBM for the treatment of OA. A total of three potential active ingredients of ZBM, including quercetin, diosmetin, and betasitosterol, were s… Show more
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