Exploring the Mechanism and discovery of potential hits to improve the treatment of pyrazinamide-resistant Mycobacterium tuberculosis
Numan Ullah,
Muhammad Shahab,
Muhammad Yaseen
et al.
Abstract:The rise of antibiotic-resistant Mycobacterium tuberculosis (MTB) has led to a reduction in the availability of effective medications for tuberculosis therapy, resulting in increased morbidity and mortality globally. Tuberculosis primarily affects the lungs but can also spread to the brain and spine. Pyrazinamide (PZA) is considered to be the most potent drug but it also shows resistance due to mutation at the position G97D. However, the Mechanism of PZA drug resistance towards Mtb PZase is unclear. Moreover, … Show more
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