Exploring the links between antibiotic occurrence, antibiotic resistance, and bacterial communities in water supply reservoirs

Huerta, Belinda; Marti, Elisabet; Gros, Meritxell; López, Pilar; Pompêo, Marcelo Luiz Martins; Armengol, Joan; Barceló, Damià; Balcázar, José Luís; Rodríguez-Mozaz, Sara; Marcé, Rafael

doi:10.1016/j.scitotenv.2013.03.071

Cited by 303 publications

(103 citation statements)

References 49 publications

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“…Moreover, VPA demonstrated that bacterial community variation was more strongly associated with ARGs than MGEs (Jordaan and Bezuidenhout 2016;Zhao et al 2016). We found that 14 genera were positively correlated with the ARG distribution, indicating that bacterial communities shaped the distribution and abundance of ARGs (Huerta et al 2013;Xiong et al 2015). Since environmental factors can greatly affect the microbial community composition, they would be expected to cause variation of ARG profiles in the urban river environment .…”

Section: Discussionmentioning

confidence: 70%

Antibiotic resistance genes in an urban river as impacted by bacterial community and physicochemical parameters

Zhou

Zheng

Wei

et al. 2017

Environ Sci Pollut Res

134

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Antibiotic resistance genes (ARGs) in urban rivers are a serious public health concern in regions with poorly planned, rapid development. To gain insights into the predominant factors affecting the fate of ARGs in a highly polluted urban river in eastern China, a total of 285 ARGs, microbial communities, and 20 physicochemical parameters were analyzed for 17 sites. A total of 258 unique ARGs were detected using high-throughput qPCR, and the absolute abundance of total ARGs was positively correlated with total organic carbon and total dissolved nitrogen concentrations (P < 0.01). ARG abundance and diversity were greatly altered by microbial community structure. Variation partitioning analysis showed that the combined effects of multiple factors contributed to the profile and dissemination of ARGs, and variation of microbial communities was the major factor affecting the distribution of ARGs. The disparate distribution of some bacteria, including Bacteroides from mammalian gastrointestinal flora, Burkholderia from zoonotic infectious diseases, and Zoogloea from wastewater treatment, indicates that the urban river was strongly influenced by point-source pollution. Results imply that microbial community shifts caused by changes in water quality may lead to the spread of ARGs, and point-source pollution in urban rivers requires greater attention to control the transfer of ARGs between environmental bacteria and pathogens.

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Section: Discussionmentioning

confidence: 70%

Antibiotic resistance genes in an urban river as impacted by bacterial community and physicochemical parameters

Zhou

Zheng

Wei

et al. 2017

Environ Sci Pollut Res

134

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“…The presence of these compounds in the aquatic environment has drawn attention because it represents a risk to ecosystems, even when found in low concentrations, as antimicrobials are designed to inactivate or destroy microorganisms, having a significant impact on the processes controlled by indigenous biological communities (HUERTA et al, 2013). Resistance to tetracycline (25%) ( Table 2) is associated with the increased and excessive use of this antimicrobial in veterinary medicine, in the treatment or prophylaxis in aquaculture (CARNEIRO et al, 2007) and with being a second choice drug in the treatment of bacterial infections in human medicine (CONCEIÇÃO et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

PROPAGATION OF ANTIMICROBIAL RESISTANT Salmonella spp. IN BIVALVE MOLLUSKS FROM ESTUARY AREAS OF BAHIA, BRAZIL

2016

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-In recent years, the emergence of resistant pathogens has complicated the treatment of bacterial infections in livestock production as well as in the medical field, due to the development of resistance mechanisms by microorganisms. The objective of this study was to delineate the antimicrobial resistance profile of Salmonella spp. strains isolated from bivalve mollusks (oysters and mussels) and from estuarine environment water of two regions of Bahia, Brazil. Twenty-seven strains, 12 isolated from bivalve mollusks and 15 from estuarine water, were tested. Eight antimicrobial agents (phenicol, beta-lactams, tetracyclines, quinolones and fluoroquinolones classes) were used for a susceptibility test, Minimum Inhibitory Concentration (MIC) and extended-spectrum beta-lactamases (ESBLs) production. Isolates showed high susceptibility to the classes of antimicrobial agents tested, with resistance only to nalidixic acid (27%), ampicillin (25%) and tetracycline (25%). Bacterial resistance was of chromosomal origin and the multidrug resistance index (MAR) among isolates of shellfish (mussels in natura) was 0.25. The MIC was found to be 100 µg/mL, 500 µg/mL and 350 µg/mL to nalidixic acid, ampicillin and tetracycline, respectively. None of the isolates presented ESBLs production. The presence of multidrug-resistant and high MIC Salmonella spp. is being conveyed in extraction areas of bivalve mollusks in the State of Bahia, Brazil.

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“…Graham et al (2011) observed significant correlations between the abundance of tetracyclines and beta-lactams ARG in river sediments and the concentration of Cu or ampicillin. Similarly, in a lacus-trine system, it was demonstrated a correlation between the presence of macrolides-related ARG, antibiotic pollution, and some bacterial community members of the phyla Actinobacteria and Firmicutes (Huerta et al 2013). The experimental approach used in these studies does not distinguish if we are in the presence of a simple co-occurrence of antibiotic residues and specific bacterial populations or genes, or if, by the contrary, significant positive correlations are due to cause-effect relationships.…”

Section: Factors Triggering Antibiotic Resistance Disseminationmentioning

confidence: 91%

“…Since domestic wastewater contains antibiotic residues, it is arguable that such residues can impose selective effects on ARB, although, as discussed above, the low concentrations found in wastewater can make this issue controversial. Some recent reports have assessed possible correlations be-tween antibiotics and metals concentration and the microbiota in wastewater or in freshwater samples (Graham et al 2011;Huerta et al 2013;Novo et al 2013;Narciso-da-Rocha et al 2014;Varela et al 2014;Rodriguez-Mozaz et al 2015). As hypothesized by the authors, these studies showed significant positive correlations between the concentration of antibiotic residues or metals and ARB&ARG or specific bacterial com-munity members in aquatic environments.…”

Section: Factors Triggering Antibiotic Resistance Disseminationmentioning

confidence: 92%

Antibiotic resistance in urban aquatic environments: can it be controlled?

Manaia

Macedo

Fatta‐Kassinos

et al. 2015

Appl Microbiol Biotechnol

172

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Over the last decade, numerous evidences have contributed to establish a link between the natural and human-impacted environments and the growing public health threat that is the antimicrobial resistance. In the environment, in particular in areas subjected to strong anthropogenic pressures, water plays a major role on the transformation and transport of contaminants including antibiotic residues, antibiotic-resistant bacteria, and antibiotic resistance genes. Therefore, the urban water cycle, comprising water abstraction, disinfection, and distribution for human consumption, and the collection, treatment, and delivery of wastewater to the environment, is a particularly interesting loop to track the fate of antibiotic resistance in the environment and to assess the risks of its trans-mission back to humans. In this article, the relevance of different transepts of the urban water cycle on the potential enrichment and spread of antibiotic resistance is reviewed. According to this analysis, some gaps of knowledge, research needs, and control measures are suggested. The critical rationale behind the measures suggested and the desirable involvement of some key action players is also discussed.

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Exploring the links between antibiotic occurrence, antibiotic resistance, and bacterial communities in water supply reservoirs

Cited by 303 publications

References 49 publications

Antibiotic resistance genes in an urban river as impacted by bacterial community and physicochemical parameters

Antibiotic resistance genes in an urban river as impacted by bacterial community and physicochemical parameters

PROPAGATION OF ANTIMICROBIAL RESISTANT Salmonella spp. IN BIVALVE MOLLUSKS FROM ESTUARY AREAS OF BAHIA, BRAZIL

Antibiotic resistance in urban aquatic environments: can it be controlled?

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