Exploring the IRE1 interactome: From canonical signaling functions to unexpected roles

Le Goupil, Simon; Laprade, Hadrien; Aubry, Marc; Chevet, Eric

doi:10.1016/j.jbc.2024.107169

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Preprint2

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 159 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Kaempferol attenuates particle-induced osteogenic impairment by regulating ER stress via the IRE1α–XBP1s pathway

Yu,

Ren,

Wang

et al. 2024

Journal of Biological Chemistry

View full text Add to dashboard Cite

Kaempferol attenuates particle-induced osteogenic impairment by regulating ER stress via the IRE1α–XBP1s pathway

Yu,

Ren,

Wang

et al. 2024

Journal of Biological Chemistry

View full text Add to dashboard Cite

Osteogenesis imperfecta type 10 and the cellular scaffolds underlying common immunological diseases

Herbert

2024

Genes Immun

View full text Add to dashboard Cite

IRF4 mediates non-enzymatic dependency on IRE1 in Multiple Myeloma cells

Oikonomidi,

Kameswaran,

Pham

et al. 2024

Preprint

View full text Add to dashboard Cite

Multiple Myeloma (MM) arises through oncogenic transformation of immunoglobulin-secreting plasma cells. MM often co-opts the endoplasmic-reticulum (ER) stress mitigator, inositol-requiring enzyme 1 (IRE1) to sustain malignant growth. While certain MMs require enzymatic IRE1-dependent activation of the ER-homeostatic transcription factor XBP1s, others display a non-enzymatic dependency on IRE1 that is not yet mechanistically understood. Interferon regulatory factor 4 (IRF4) stimulates gene programs that promote immune-cell proliferation and plays an essential role in MM. Here we show that the non-enzymatic reliance on IRE1 in MM entails IRF4. IRE1 silencing increased inhibitory phosphorylation of IRF4, disrupting its chromatin-binding activity and mRNA transcription. IRF4 knockdown recapitulated, whereas IRF4 re-expression reversed the anti-proliferative phenotype of IRE1 silencing. Mechanistic studies revealed that IRF4 engages the E2F1 and CDC25A genes and promotes CDK2 activation to drive cell cycle progression. Our results uncover an unexpected functional link between IRE1 and IRF4 in MM.

show abstract

Exploring the IRE1 interactome: From canonical signaling functions to unexpected roles

Cited by 4 publications

References 159 publications

Kaempferol attenuates particle-induced osteogenic impairment by regulating ER stress via the IRE1α–XBP1s pathway

Kaempferol attenuates particle-induced osteogenic impairment by regulating ER stress via the IRE1α–XBP1s pathway

Osteogenesis imperfecta type 10 and the cellular scaffolds underlying common immunological diseases

IRF4 mediates non-enzymatic dependency on IRE1 in Multiple Myeloma cells

Contact Info

Product

Resources

About