Exploring the Involvement of Gut Microbiota in Cancer Therapy-Induced Cardiotoxicity

Kunika,; Frey, Norbert; Rangrez, Ashraf Yusuf

doi:10.3390/ijms24087261

Cited by 6 publications

(1 citation statement)

References 108 publications

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“…Considering that gut microbiome composition is crucial for shaping the immune system, the associations between the gut microbiome and treatment-induced late effects are gaining attention. In this context, a lot of evidence has documented the impact of dysbiosis on the function of the nervous and cardiovascular systems [ 152 ], and numerous clinical trials are still ongoing ( Table 1 ).…”

Section: Microbiome and Therapy-induced Late Effectsmentioning

confidence: 99%

Microbiome in Cancer Development and Treatment

Ciernikova,

Sevcikova,

Mladosievicova

et al. 2023

Microorganisms

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Targeting the microbiome, microbiota-derived metabolites, and related pathways represents a significant challenge in oncology. Microbiome analyses have confirmed the negative impact of cancer treatment on gut homeostasis, resulting in acute dysbiosis and severe complications, including massive inflammatory immune response, mucosal barrier disruption, and bacterial translocation across the gut epithelium. Moreover, recent studies revealed the relationship between an imbalance in the gut microbiome and treatment-related toxicity. In this review, we provide current insights into the role of the microbiome in tumor development and the impact of gut and tumor microbiomes on chemo- and immunotherapy efficacy, as well as treatment-induced late effects, including cognitive impairment and cardiotoxicity. As discussed, microbiota modulation via probiotic supplementation and fecal microbiota transplantation represents a new trend in cancer patient care, aiming to increase bacterial diversity, alleviate acute and long-term treatment-induced toxicity, and improve the response to various treatment modalities. However, a more detailed understanding of the complex relationship between the microbiome and host can significantly contribute to integrating a microbiome-based approach into clinical practice. Determination of causal correlations might lead to the identification of clinically relevant diagnostic and prognostic microbial biomarkers. Notably, restoration of intestinal homeostasis could contribute to optimizing treatment efficacy and improving cancer patient outcomes.

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Section: Microbiome and Therapy-induced Late Effectsmentioning

confidence: 99%