Exploring the inhibition mechanism of interleukin-1-beta in gouty arthritis by polygonum cuspidatum using network pharmacology and molecular docking: A review

Ge, Xin; Zhang, Yan; Fang, Rulu; Zhao, Jiaojiao; Huang, Jiyong

doi:10.1097/md.0000000000034396

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…During oxidative stress, excessive reactive oxygen species are produced, leading to cellular oxidative damage and subsequent inflammation, apoptosis, and tissue injury [23]. The oxidative stress pathway includes antioxidant enzyme systems, redox reactions, and free radical scavenging mechanisms [24]. Modulating these pathways can improve oxidative stress status.…”

Section: Active Ingredient Information and Target Prediction Of Odpsmentioning

confidence: 99%

Study on the Mechanism of Opuntia Dillenii Polysaccharide against Cadmium-Induced Liver Injury Based on Network Pharmacology and Oxidative Stress Pathway

Zhou,

Liu,

et al. 2023

J Liver Clin Res

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This study aims to investigate the mechanism of action of Opuntia dillenii polysaccharides (ODPs) in protecting against cadmium-induced liver injury from the perspectives of network pharmacology and oxidative stress pathway. Using network pharmacology methods, we analyzed the interactions between ODPs and target molecules, and predicted potential mechanisms of action. Additionally, we focused on the oxidative stress pathway, which plays a crucial role in cadmium-induced liver injury. The results showed that the active components of ODPs were glucuronic acid, galacturonic acid, rhamnose, fucose, glucose, galactose, mannose, fructose, xylose and arabinose in order. According to the analysis of PPI network and the “compound - liver injury target-pathway” network, 69 ODPs anti-cadmium-induced liver injury targets were selected, including AKT1, CASP3, MAPK8, JAK2, MAPK14, IL2, MMP9, IGF1R, NOS2, etc. Enrichment analysis showed that the main signaling pathways involved were VEGF signaling pathway, cancer signaling pathway, PI3K-AKT signaling pathway, Rap1 signaling pathway, Ras signaling pathway, chemokine signaling pathway, sphingolipid signaling pathway, toll-like receptor signaling pathway, tumor necrosis factor signaling pathway, and MAPK signaling pathway. Network pharmacological analysis showed that cactus polysaccharide could significantly reduce the level of Caspase-3 and MMP-9 in liver, increase the level of IL-2, and effectively inhibit the occurrence of liver cell apoptosis and inflammation caused by cadmium. Studies on the mechanism of action based on traditional oxidative stress indexes show that ODPs has good antioxidant capacity, can significantly inhibit the activity of SOD and GSH-PX caused by cadmium, reduce the content of lipid peroxidation product MDA, and restore the content of antioxidant enzymes in liver to normal level. This study can provide a scientific basis for the in-depth development and application of ODPs, and also provide a potential scientific and technological basis for the development of drugs or health food for the treatment of cadmium-induced liver injury.

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Section: Active Ingredient Information and Target Prediction Of Odpsmentioning

confidence: 99%

Study on the Mechanism of Opuntia Dillenii Polysaccharide against Cadmium-Induced Liver Injury Based on Network Pharmacology and Oxidative Stress Pathway

Zhou,

Liu,

et al. 2023

J Liver Clin Res

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Advancements in the study of IL-6 and its receptors in the pathogenesis of gout

Zhang,

Wang,

Xiong

et al. 2024

Cytokine

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Network pharmacology and molecular docking to explore the treatment potential and molecular mechanism of Si-Miao decoction against gouty arthritis

Ma,

Zeng,

Feng

et al. 2024

Medicine

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Gouty arthritis (GA) is a common metabolic rheumatological disease. Si-Miao decoction has therapeutic effects on GA. In our study, we investigated the mechanism of Si-Miao decoction against GA using network pharmacology and molecular docking analytical methods. The Traditional Chinese Medicine Systems Pharmacology Database was used as the basis for screening the main targets and agents of the Si-Miao decoction, and the Genecards, OMIM, and Drugbank databases were used to screen GA-related targets. They were analyzed using Venn with the drug targets to obtain the intersection targets. We used Cytoscape 3.9.1 to draw the “Drugs-Compounds-Targets” network and the String database for creative protein-protein interaction networks of target genes and filtered core targets. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were used to analyze the core targets. Molecular docking was performed using AutoDockTools to predict the binding capacity between nuclear targets and active components in the Si-Miao decoction. A total of 50 chemically active components containing 53 common targets of Si-Miao decoction anti-GA and 53 potential drug target proteins were identified. Core targets, namely, TNF, STAT3, SRC, PPARG, TLR4, PTGS2, MMP9, RELA, TGFB1, and SIRT1, were obtained through PPI network analysis. GO and KEGG analyses showed that the mechanism of anti-GA in Si-Miao decoction may proceed by regulating biological processes such as inflammatory factor levels, cell proliferation, apoptosis, and lipid and glucose metabolism, and modulating the NOD-like receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, NF-kappa B signaling pathway, and Toll-like receptor signaling pathway. We further screened the core targets, including PTGS2, MMP9, and PPAGR, as receptor proteins based on their degree value and molecular docking with the main active compounds in Si-Miao decoction, and found that baicalein had high affinity. In conclusion, Si-Miao decoction, through anti-inflammatory, apoptosis-regulating, and anti-oxidative stress action mechanisms in the treatment of GA.

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Exploring the inhibition mechanism of interleukin-1-beta in gouty arthritis by polygonum cuspidatum using network pharmacology and molecular docking: A review

Cited by 3 publications

References 38 publications

Study on the Mechanism of Opuntia Dillenii Polysaccharide against Cadmium-Induced Liver Injury Based on Network Pharmacology and Oxidative Stress Pathway

Study on the Mechanism of Opuntia Dillenii Polysaccharide against Cadmium-Induced Liver Injury Based on Network Pharmacology and Oxidative Stress Pathway

Advancements in the study of IL-6 and its receptors in the pathogenesis of gout

Network pharmacology and molecular docking to explore the treatment potential and molecular mechanism of Si-Miao decoction against gouty arthritis

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