Exploring the Influence of Zinc Ions on the Conformational Stability and Activity of Protein Disulfide Isomerase
Ana Iochabel Soares Moretti,
Viktoria E. Baksheeva,
Andrei Yu. Roman
et al.
Abstract:The interplay between metal ion binding and the activity of thiol proteins, particularly within the protein disulfide isomerase family, remains an area of active investigation due to the critical role that these proteins play in many vital processes. This research investigates the interaction between recombinant human PDIA1 and zinc ions, focusing on the subsequent implications for PDIA1’s conformational stability and enzymatic activity. Employing isothermal titration calorimetry and differential scanning calo… Show more
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