Exploring the impact of sodium salts on hydrotropic solubilization

Benfica, Jordana; Martins, Afonso C.; Peréz-Sanchéz, Germán; Schaeffer, Nicolas; Coutinho, João A. P.

doi:10.1039/d3cp02034g

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…Ideally, solubility enhancement with hydrotrope concentration should attain a sigmoidal curve shape; however, here, all DES-based systems deviate from the sigmoidal shape perhaps because of the presence of specific interactions between ETA with DES. Similar findings have been reported in the literature earlier. − The quantitative trend in water intake depends on the structure of the constituents of the DES. The initial maximum of w o observed for (Thy: DA) lies in the ETA concentration range between 0.9 and 1.5 M; for (Men: DA), it is between 0.8 and 1.6 M; for (Lin: DA), it is between 0.5 and 1.2 M; for (Cit: DA), it is between 0.5 and 1.1 M; and for (Ger: DA), it is between 0.7 and 1.8 M.…”

Section: Results and Discussionsupporting

confidence: 89%

Formation of Ethanolamine-Mediated Surfactant-Free Microemulsions Using Hydrophobic Deep Eutectic Solvents

Anjali,

Pandey

2024

Langmuir

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Hydrophobic deep eutectic solvents (HDESs) are emerging as versatile, relatively benign, and inexpensive alternatives to conventional organic solvents in a diverse set of applications. In this context, the formation of microemulsions with HDES replacing the oil phase has become an area of active exploration. Because of recent reports on the undesirable toxicity of many common surfactants, efforts are under way to investigate the formation of surfactant-free microemulsions (SFMEs) using HDES as an oil phase. We present SFME formation using HDESs constituted of n-decanoic acid and five (5) structurally different terpenoids [thymol, l(−)-menthol, linalool, β-citronellol, and geraniol] at a 1:1 molar ratio as the oil phase and water as the hydrophilic phase. Ethanolamine (ETA) exhibited the best potential as a hydrotrope among several other similar small molecules. Results showed a drastic increase in water solubility within the HDESs in the presence of ETA. ETA exerted its hydrotropic action at different extent for each DES system via chemical interaction with the H-bond donor (HBD) constituent of the HDES. The optimum hydrotropic concentration (minimum hydrotrope and maximum water retention, X ETA OPT) assigned for each DES/ETA/water system and water loading are reported, and the trends are discussed in detail. Ternary phase diagrams are constructed using visual observation and the dye staining method. The area under the single- and multiple-phase regions (assigned in ternary phase diagrams) was estimated. “Pre-Ouzo” enforced by ETA was investigated using dynamic light scattering (DLS) of the DES/ETA/water systems at X ETA OPT. A systematic growth in nanoaggregates was observed with the subsequent addition of water in DES/ETA systems while continuously changing the existing microstructure. The presence of a core (oil)–shell (water)-like structure as indicated by the fluorescence response of Nile red in the “pre-Ouzo” region is speculated. We were able to prepare a homogeneous solution of [K3Fe(CN)6] salt in “pre-Ouzo” mixtures with no apparent deviation in the Beer–Lambert law.

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Section: Results and Discussionsupporting

confidence: 89%