Exploring the Impact of Nutrition on Non-Alcoholic Fatty Liver Disease Management: Unveiling the Roles of Various Foods, Food Components, and Compounds

Kosmalski, Marcin; Frankowski, Rafał; Deska, Kacper; Różycka-Kosmalska, Monika; Pietras, Tadeusz

doi:10.3390/nu15132838

Cited by 2 publications

(2 citation statements)

References 220 publications

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“…It is well known that obesity can lead to NAFLD ( 25 ). Therefore, in the present study, we enrolled an age- and BMI-matched control group with no statistical difference in BMI, WHR, body fat percentage, or VFA to the experimental group, thereby reducing the bias in the results potentially caused by obesity.…”

Section: Discussionmentioning

confidence: 99%

Controlled attenuation parameters to assess liver steatosis in obese patients with polycystic ovary syndrome

Wang,

Nan,

Bing

et al. 2023

Front. Endocrinol.

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ObjectivesThis study was performed to investigate the changes and influencing factors of liver controlled attenuation parameter (CAP) in obese patients with polycystic ovary syndrome (PCOS), and to determine the prevalence and risk factors of nonalcoholic fatty liver disease (NAFLD) in PCOS patients with obesity.MethodsForty-one PCOS patients with obesity and twenty age- and body mass index (BMI)-matched control women without PCOS were enrolled in this study. General data, body composition, biochemical parameters, sex hormones, and liver CAP in the two groups were collected and compared. Liver CAP was measured using transient elastography.ResultsNAFLD was more common in the Obese PCOS group than in the control group (75.61% vs. 45.00%, P=0.018). Compared to the control group, the obese PCOS group showed apparent increases in alanine transaminase (ALT), aspartate transaminase (AST), CAP, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), totle testosterone (TT), free androgen index (FAI), fasting insulin (FIns), and homeostasis model assessment-insulin resistance (HOMA-IR), along with lower high-density lipoprotein cholesterol (HDL-C) and sex hormone binding globulin (SHBG) levels. In addition, as shown by Spearman analysis, liver CAP in PCOS patients with obesity had a positive correlation with ALT, AST, TG, TT, FAI, FIns, and HOMA-IR, and a negative correlation with SHBG. Logistic regression analysis showed that TG, TT, FIns, and HOMA-IR were risk factors for NAFLD, while TT was an independent risk factor for NAFLD in PCOS patients with obesity.ConclusionPCOS patients with obesity had a significantly higher prevalence of NAFLD. Furthermore, in PCOS patients with obesity, liver CAP was associated with disorders of lipid metabolism, insulin resistance, and hyperandrogenemia, with elevated testosterone levels being an independent risk factor for NAFLD in PCOS patients with obesity.

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Section: Discussionmentioning

confidence: 99%

Controlled attenuation parameters to assess liver steatosis in obese patients with polycystic ovary syndrome

Wang,

Nan,

Bing

et al. 2023

Front. Endocrinol.

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“…Despite significant advancements in understanding the underlying mechanisms of MASLD, there is still a lack of effective pharmaceuticals to intervene and treat MASLD. Given the role of oxidative stress in the pathogenesis of MASLD, a growing number of studies have focused on how to enhance the body's antioxidant capacity to prevent or stop the progression of MASLD [7]. Available options include increasing dietary antioxidant intake and exercise.…”

Section: Introductionmentioning

confidence: 99%

Trends in Oxidative Balance Score and Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in the United States: National Health and Nutrition Examination Survey 2001 to 2018

Tan,

Wu,

Meng

et al. 2023

Nutrients

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Background: Most studies have primarily focused on assessing the association between diet or exercise patterns and metabolic dysfunction-associated steatotic liver disease (MASLD). This study adopted a more comprehensive approach by introducing the oxidative balance score (OBS) to evaluate the combined effects of diet and lifestyle on the body’s antioxidant ability. Our main objective was to investigate the association between OBS and the burden of MASLD in the United States. Methods: Participants with complete information from 2001 to 2018 were included. In the absence of other definite liver injury factors, the United States fatty liver index (us-FLI) ≥ 30 was used as the diagnostic criterion for MASLD. We first calculated the weighted prevalence for each cycle and stratified it according to demographic and metabolic-related disease characteristics. Subsequently, weighted multiple logistic regression was used to evaluate the relationship between OBS and MASLD. In addition, we explored the body’s inflammatory state and the level of insulin resistance (IR) in mediating OBS and MASLD. Results: From 2001 to 2018, the prevalence of MASLD in the U.S. population as a whole increased from 29.76% to 36.04%, and the rate was higher in people with metabolic-related diseases. Notably, OBS exhibited a negative correlation with MASLD. Participants in the highest tertile of OBS had a significantly lower prevalence of MASLD compared to those in the lowest tertile [OR: 0.72, 95%CI: (0.57, 0.92), p < 0.001]. Moreover, a high OBS is associated with a lower inflammatory state and level of IR. The body’s inflammatory state and IR level mediated the association between OBS and MASLD by 5.2% and 39.7%, respectively (both p < 0.001). Conclusions: In this study, we observed an increasing prevalence of MASLD over the years. A higher OBS was associated with a lower risk of MASLD, especially when OBS ≥ 25. The body’s inflammatory state and IR level mediate the association between OBS and MASLD, but the mechanism needs to be further investigated.

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Exploring the Impact of Nutrition on Non-Alcoholic Fatty Liver Disease Management: Unveiling the Roles of Various Foods, Food Components, and Compounds

Cited by 2 publications

References 220 publications

Controlled attenuation parameters to assess liver steatosis in obese patients with polycystic ovary syndrome

Controlled attenuation parameters to assess liver steatosis in obese patients with polycystic ovary syndrome

Trends in Oxidative Balance Score and Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in the United States: National Health and Nutrition Examination Survey 2001 to 2018

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