Exploring the impact of continuous positive airway pressure treatment on biological clock disruption in obstructive sleep apnea patients

Gaspar, Laetitia S.; Hesse, Janina; Yalcin, Muhittin; Santos, Bárbara; Carvalhas-Almeida, Catarina; Ferreira, Muriel; Moita, Joaquim; Relógio, Angela; Cavadas, Cláudia; Álvaro, Ana Rita

doi:10.1183/23120541.sleepandbreathing-2021.79

Cited by 1 publication

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“…Another recent study by Gaspar et al confirmed (Gaspar et al, 2021). In regard to melatonin rhythms in OSA, it is worth noting that study results are not uniform, with some authors reporting altered levels of plasma melatonin in OSA patients in comparison with controls that were not reversed by CPAP administration (Lemmer et al, 2016), while others did not find differences between OSA patients and controls in circadian phase, evaluated by salivary melatonin concentration (Papaioannou et al, 2012).…”

Section: Influence Of Circadian Rhythms On Osamentioning

confidence: 85%

“…Recent gene expression studies provide increasing evidence that circadian dysregulation accompanies obstructive sleep apnea and is involved in the progression of OSA-related comorbidities, however, the results are inconclusive (Burioka et al, 2008;Gabryelska et al, 2022;Gaspar et al, 2021;Moreira et al, 2017;Soreca, 2021;von Allmen et al, 2018;Yang et al, 2019).…”

Section: Links Between Osa and Circadian Rhythm Disordersmentioning

confidence: 99%

“…Interestingly, certain patient subgroups differed in their response to CPAP; notably, age above 55 years was associated with more pronounced alterations in circadian gene expression rhythm. The mechanisms underlying the differential response to short and long-term CPAP treatment remain to be elucidated (Gaspar et al, 2021).…”

Section: Influence Of Circadian Rhythms On Osamentioning

confidence: 99%

“…In line with recent advancements in the understanding of circadian biology and its role in human disease, several methodologically heterogeneous studies have demonstrated altered core clock gene expression patterns in patients with obstructive sleep apnea (Burioka et al, 2008;Gaspar et al, 2021;Moreira et al, 2017;Yang et al, 2019). Although the exact mechanisms remain to be elucidated, the interaction between obstructive sleep apnea and circadian dysregulation appears to be bidirectional.…”

mentioning

confidence: 98%

“…Recent research implies the role of circadian rhythm dysregulation in the development and progression of OSA-related comorbidities (Burioka et al, 2008;Gaspar et al, 2021;Moreira et al, 2017;Xie et al, 2022;Yang et al, 2019). Circadian rhythms are endogenous rhythms with a 24 h periodicity that temporally optimise behaviour and physiology (Patke et al, 2020).…”

mentioning

confidence: 99%

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Is obstructive sleep apnea a circadian rhythm disorder?

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et al. 2023

Journal of Sleep Research

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Obstructive sleep apnea is the most common sleep-related breathing disorder worldwide and remains underdiagnosed. Its multiple associated comorbidities contribute to a decreased quality of life and work performance as well as an increased risk of death. Standard treatment seems to have limited effects on cardiovascular and metabolic aspects of the disease, emphasising the need for early diagnosis and additional therapeutic approaches. Recent evidence suggests that the dysregulation of circadian rhythms, processes with endogenous rhythmicity that are adjusted to the environment through various cues, is involved in the pathogenesis of comorbidities.In patients with obstructive sleep apnea, altered circadian gene expression patterns have been demonstrated. Obstructive respiratory events may promote circadian dysregulation through the effects of sleep disturbance and intermittent hypoxia, with subsequent inflammation and disruption of neural and hormonal homeostasis. In this review, current knowledge on obstructive sleep apnea, circadian rhythm regulation, and circadian rhythm sleep disorders is summarised. Studies that connect obstructive sleep apnea to circadian rhythm abnormalities are critically evaluated. Furthermore, pathogenetic mechanisms that may underlie this association, most notably hypoxia signalling, are presented. A bidirectional relationship between obstructive sleep apnea and circadian rhythm dysregulation is proposed. Approaching obstructive sleep apnea as a circadian rhythm disorder may prove beneficial for the development of new, personalised diagnostic, therapeutic and prognostic tools. However, further studies are needed before the clinical approach to obstructive sleep apnea includes targeting the circadian system.

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Section: Influence Of Circadian Rhythms On Osamentioning

confidence: 85%