Exploring the half-life of glyphosate in human urine samples

Connolly, Alison; Jones, Kate; Basinas, Ioannis; Galea, Karen S.; Kenny, Laura; McGowan, Padraic; Coggins, Marie

doi:10.1016/j.ijheh.2018.09.004

Cited by 91 publications

(45 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Zoller et al (2020) also provides valuable first insights into human urinary excretion kinetics with peak concentrations occurring in urine approximately 5 h after oral uptake and an elimination half time of around 9 h [ 30 ]. Interestingly, their findings are rather similar to Connolly et al (2019), who estimated the elimination half times in urine samples collected from seven amenity horticulture workers after spraying glyphosate to be between 5 ½ to 10 h [ 48 ]. Overall, these findings are lower than the urinary elimination kinetics known from animal studies, where the urinary half-life was calculated to be 72 h (50% elimination at 12 h) [ 68 ] and 48 h [ 3 , 69 ].…”

Section: Discussionsupporting

confidence: 80%

“…Curwin et al (2007) conducted a study of farm and non-farm families and found that the non-farm family’s children had higher urinary glyphosate concentrations, which was assumed to be from residential use of glyphosate-based pesticide products [ 24 ]. Although urine samples were collected up to 5 days after pesticide application and glyphosate has a very short half-life [ 48 ], peak exposures may have been missed, which could partially be the reason for having no reported differences between the two groups. The study also observed a correlation between farmer urinary pesticide concentrations and spouse and children’s urinary concentrations [ 24 , 49 ], possibly due to para-occupational exposures among family members.…”

Section: Human Biomonitoring Studies On Glyphosatementioning

confidence: 99%

See 1 more Smart Citation

Human Biomonitoring of Glyphosate Exposures: State-of-the-Art and Future Research Challenges

Connolly

Coggins

Koch

2020

Toxics

Self Cite

View full text Add to dashboard Cite

Glyphosate continues to attract controversial debate following the International Agency for Research on Cancer carcinogenicity classification in 2015. Despite its ubiquitous presence in our environment, there remains a dearth of data on human exposure to both glyphosate and its main biodegradation product aminomethylphosphonic (AMPA). Herein, we reviewed and compared results from 21 studies that use human biomonitoring (HBM) to measure urinary glyphosate and AMPA. Elucidation of the level and range of exposure was complicated by differences in sampling strategy, analytical methods, and data presentation. Exposure data is required to enable a more robust regulatory risk assessment, and these studies included higher occupational exposures, environmental exposures, and vulnerable groups such as children. There was also considerable uncertainty regarding the absorption and excretion pattern of glyphosate and AMPA in humans. This information is required to back-calculate exposure doses from urinary levels and thus, compared with health-based guidance values. Back-calculations based on animal-derived excretion rates suggested that there were no health concerns in relation to glyphosate exposure (when compared with EFSA acceptable daily intake (ADI)). However, recent human metabolism data has reported as low as a 1% urinary excretion rate of glyphosate. Human exposures extrapolated from urinary glyphosate concentrations found that upper-bound levels may be much closer to the ADI than previously reported.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Human Biomonitoring Studies On Glyphosatementioning

confidence: 99%

Human Biomonitoring of Glyphosate Exposures: State-of-the-Art and Future Research Challenges

Connolly

Coggins

Koch

2020

Toxics

Self Cite

View full text Add to dashboard Cite

show abstract

“…The current “safe” standard set by the Environmental Protection Agency (EPA) for daily chronic reference dose of glyphosate is 1.75 milligrams per kilogram of body weight 1 . The no observable adverse effect level (NOAEL) is 50 mg/kg per day dose 2 . The allowed industry exposure levels are 2.5–4.5 mg/kg per day 2 .…”

Section: Introductionmentioning

confidence: 99%

“…The no observable adverse effect level (NOAEL) is 50 mg/kg per day dose 2 . The allowed industry exposure levels are 2.5–4.5 mg/kg per day 2 . High exposure dose studies involving 50–500 mg/kg per day have been reported 3–9 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology

Kubsad

Nilsson

King

et al. 2019

Sci Rep

163

134

View full text Add to dashboard Cite

Ancestral environmental exposures to a variety of factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. One of the most widely used agricultural pesticides worldwide is the herbicide glyphosate (N-(phosphonomethyl)glycine), commonly known as Roundup. There are an increasing number of conflicting reports regarding the direct exposure toxicity (risk) of glyphosate, but no rigorous investigations on the generational actions. The current study using a transient exposure of gestating F0 generation female rats found negligible impacts of glyphosate on the directly exposed F0 generation, or F1 generation offspring pathology. In contrast, dramatic increases in pathologies in the F2 generation grand-offspring, and F3 transgenerational great-grand-offspring were observed. The transgenerational pathologies observed include prostate disease, obesity, kidney disease, ovarian disease, and parturition (birth) abnormalities. Epigenetic analysis of the F1, F2 and F3 generation sperm identified differential DNA methylation regions (DMRs). A number of DMR associated genes were identified and previously shown to be involved in pathologies. Therefore, we propose glyphosate can induce the transgenerational inheritance of disease and germline (e.g. sperm) epimutations. Observations suggest the generational toxicology of glyphosate needs to be considered in the disease etiology of future generations.

show abstract

Human Biomonitoring

최덕천¹

2021

Monitoring for Health Hazards at Work

View full text Add to dashboard Cite

Exploring the half-life of glyphosate in human urine samples

Cited by 91 publications

References 29 publications

Human Biomonitoring of Glyphosate Exposures: State-of-the-Art and Future Research Challenges

Human Biomonitoring of Glyphosate Exposures: State-of-the-Art and Future Research Challenges

Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology

Human Biomonitoring

Contact Info

Product

Resources

About