Exploring the gut microbiota and its potential as a biomarker in gliomas

Aljarrah, Dana; Chalour, Naima; Zorgani, Amine; Nissan, Tracy; Pranjol, Md Zahidul I.

doi:10.1016/j.biopha.2024.116420

Cited by 4 publications

(2 citation statements)

References 193 publications

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“…The presence of a brain-gut axis allows the gut and brain to interact. Gut microbes are able to regulate the function of various cells in the brain through a variety of metabolites they produce ( 25 ). Prior researches indicated that the gut microbiota may play a role in the occurrence, progression, and treatment of gliomas through metabolic regulation of the epigenetic and immune microenvironment.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota’s role in glioblastoma risk, with a focus on the mediating role of metabolites

Yan,

Li,

Luo

2024

Front. Neurol.

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This study employed Mendelian randomization (MR) analysis to systematically investigate the potential connections between gut microbiota and the risk of glioblastoma (GBM). We identified 12 microbial groups closely associated with the incidence risk of GBM. Subsequently, MR analysis was conducted on 1,091 blood metabolites and 309 metabolite ratios, revealing 19 metabolites that exert an impact on the occurrence of GBM. Hypothesizing that gut microbiota may influence the risk of glioblastoma multiforme by modulating these metabolites, we performed MR analyses, considering each microbial group as exposure and each metabolite as an outcome. Through these analyses, we constructed a regulatory network encompassing gut microbiota, metabolites, and GBM, providing a novel perspective for a deeper understanding of the role of the gut-brain axis in the pathogenesis of GBM. This research offers crucial insights into how gut microbiota may affect the risk of GBM by regulating specific metabolites. The identified regulatory network of the gut-brain axis may play a significant role in the formation and development of GBM, providing valuable information for future research and therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota’s role in glioblastoma risk, with a focus on the mediating role of metabolites

Yan,

Li,

Luo

2024

Front. Neurol.

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“…Metabolites and signaling pathway regulation: Metabolites produced by gut microbiota can reach the brain through blood circulation, affecting the metabolism and signal transduction of GBM cells ( 27 ). For example, certain metabolites such as bile acids and indole compounds may activate specific signaling pathways within GBM cells, affecting tumor cell proliferation, migration, angiogenesis, and immune escape ability ( 28 , 29 ).…”

Section: The Mutual Regulatory Effect Between Gut Microbiota and The ...mentioning

confidence: 99%

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Zhang,

Hong,

et al. 2024

Front. Immunol.

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Glioblastoma (GBM) is a highly malignant, invasive, and poorly prognosed brain tumor. Unfortunately, active comprehensive treatment does not significantly prolong patient survival. With the deepening of research, it has been found that gut microbiota plays a certain role in GBM, and can directly or indirectly affect the efficacy of immune checkpoint inhibitors (ICIs) in various ways. (1) The metabolites produced by gut microbiota directly affect the host’s immune homeostasis, and these metabolites can affect the function and distribution of immune cells, promote or inhibit inflammatory responses, affect the phenotype, angiogenesis, inflammatory response, and immune cell infiltration of GBM cells, thereby affecting the effectiveness of ICIs. (2) Some members of the gut microbiota may reverse T cell function inhibition, increase T cell anti-tumor activity, and ultimately improve the efficacy of ICIs by targeting specific immunosuppressive metabolites and cytokines. (3) Some members of the gut microbiota directly participate in the metabolic process of drugs, which can degrade, transform, or produce metabolites, affecting the effective concentration and bioavailability of drugs. Optimizing the structure of the gut microbiota may help improve the efficacy of ICIs. (4) The gut microbiota can also regulate immune cell function and inflammatory status in the brain through gut brain axis communication, indirectly affecting the progression of GBM and the therapeutic response to ICIs. (5) Given the importance of gut microbiota for ICI therapy, researchers have begun exploring the use of fecal microbiota transplantation (FMT) to transplant healthy or optimized gut microbiota to GBM patients, in order to improve their immune status and enhance their response to ICI therapy. Preliminary studies suggest that FMT may enhance the efficacy of ICI therapy in some patients. In summary, gut microbiota plays a crucial role in regulating ICIs in GBM, and with a deeper understanding of the relationship between gut microbiota and tumor immunity, it is expected to develop more precise and effective personalized ICI therapy strategies for GBM, in order to improve patient prognosis.

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Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis

Kim,

Lim,

2024

Biomedicine & Pharmacotherapy

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Exploring the gut microbiota and its potential as a biomarker in gliomas

Cited by 4 publications

References 193 publications

Gut microbiota’s role in glioblastoma risk, with a focus on the mediating role of metabolites

Gut microbiota’s role in glioblastoma risk, with a focus on the mediating role of metabolites

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis

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