Exploring the Fundamentals of Microreactor Technology with Multidisciplinary Lab Experiments Combining the Synthesis and Characterization of Inorganic Nanoparticles

Emmanuel, Noémie; Emonds-Alt, Gauthier; Lismont, Marjorie; Eppe, Gauthier; Monbaliu, Jean‐Christophe M.

doi:10.1021/acs.jchemed.6b00899

Cited by 17 publications

(15 citation statements)

References 37 publications

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“…Also because microreaction systems are mini‐continuous plants in lab, the microreactor‐centered “flow chemistry” systems have been considered as effective approaches for preparing nanomaterials in large amounts . However, despite over 10 years' development, microreaction technology is still mainly used for lab research with few reports showing the transitions from academics to industrialization . To fill over the gaps between scientific researches and engineering productions of nanocrystals, engineering innovations of flow chemistry technology should be more sufficiently developed to build bridges between chemists, material scientists, and engineers.…”

Section: Introductionmentioning

confidence: 99%

Continuous Synthesis of Nanocrystals via Flow Chemistry Technology

Sui

Yan

Liu

et al. 2019

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Modern nanotechnologies bring humanity to a new age, and advanced methods for preparing functional nanocrystals are cornerstones. A considerable variety of nanomaterials has been created over the past decades, but few were prepared on the macro scale, even fewer making it to the stage of industrial production. The gap between academic research and engineering production is expected to be filled by flow chemistry technology, which relies on microreactors. Microreaction devices and technologies for synthesizing different kinds of nanocrystals are discussed from an engineering point of view. The advantages of microreactors, the important features of flow chemistry systems, and methods to apply them in the syntheses of salt, oxide, metal, alloy, and quantum dot nanomaterials are summarized. To further exhibit the scaling‐up of nanocrystal synthesis, recent reports on using microreactors with gram per hour and larger production rates are highlighted. Finally, an industrial example for preparing 10 tons of CaCO3 nanoparticles per day is introduced, which shows the great potential for flow chemistry processes to transfer lab research to industry.

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Section: Introductionmentioning

confidence: 99%

Continuous Synthesis of Nanocrystals via Flow Chemistry Technology

Sui

Yan

Liu

et al. 2019

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“…The laboratory exercise seeks to build upon students' prior knowledge of diffusion and mass transport to demonstrate the difference between flow and batch processes as well as the advantage of microscale reactions. Wanting to simplify microfluidic fabrication for the students, Emmanuel et al 32 decided to use capillary coils as microreactors for the synthesis of inorganic nanoparticles. With this approach, students could easily assemble their systems using high-performance liquid chromatography (HPLC) connectors and could interchange capillaries of different diameters to study the effect of residence time without changing the mixing efficiency.…”

Section: Synthetic Chemistrymentioning

confidence: 99%

“Learning on a chip:” Microfluidics for formal and informal science education

2019

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Microfluidics is a technique for the handling of small volumes of liquids on the order of picoliters to nanoliters and has impact for miniaturized biomedical science and fundamental research. Because of its multi-and interdisciplinary nature (i.e., combining the fields of biology, chemistry, physics, and engineering), microfluidics offers much potential for educational applications, both at the university level as well as primary and secondary education. Microfluidics is also an ideal "tool" to enthuse and educate members of the general public about the interdisciplinary aspects of modern sciences, including concepts of science, technology, engineering, and mathematics subjects such as (bio)engineering, chemistry, and biomedical sciences. Here, we provide an overview of approaches that have been taken to make microfluidics accessible for formal and informal learning. We also point out future avenues and desired developments. At the extreme ends, we can distinguish between projects that teach how to build microfluidic devices vs projects that make various microscopic phenomena (e.g., low Reynolds number hydrodynamics, microbiology) accessible to learners and the general public. Microfluidics also enables educators to make experiments low-cost and scalable, and thereby widely accessible. Our goal for this review is to assist academic researchers working in the field of microfluidics and lab-on-a-chip technologies as well as educators with translating research from the laboratory into the lecture hall, teaching laboratory, or public sphere.

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“…It is hence crucial to be able to introduce the most basic concepts and capabilities of microfluidics at the high school or undergraduate level. Performing microfluidic experiments, however, necessitate the usage of microsystems, injection control instruments and microscopes [4][5][6][7][8][9] that are rarely available in undergraduate teaching laboratories.…”

Section: Capsum Company)mentioning

confidence: 99%

“…We have built in this document a digital millifluidic experimental setup allowing the kinetics quantification of the redox reaction of a dye, erythrosine B, with bleach. As compared to existing protocols aiming at introducing microfluidics concepts and available in the teaching literature [4][5][6][7][8][9] , the full setup can be built from materials and chemicals widely available in chemistry laboratories for undergraduate students. The setup does not require the acquisition of specific and more expensive instruments such as pressure regulators or microfabricated devices.…”

Section: Pedagogical Considerationsmentioning

confidence: 99%

An introduction to digital microfluidic concepts in chemistry using a macroscopic droplet generator

C¹,

Fattaccioli²,

Jacq³

2018

Preprint

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<div><div><div><div><div><div><p>This activity introduces digital microfluidics and the usage of aqueous droplets as independent chemical microreactors for reaction kinetics studies. Students build their own droplet generator from common macroscopic glassware and connecting parts, to create trains of millimetric droplets in which a redox reaction takes place. The activity allows working on reaction kinetics, hydrodynamics at low Reynolds number and image analysis at a macroscopic scale.</p></div></div></div></div></div></div>

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Exploring the Fundamentals of Microreactor Technology with Multidisciplinary Lab Experiments Combining the Synthesis and Characterization of Inorganic Nanoparticles

Cited by 17 publications

References 37 publications

Continuous Synthesis of Nanocrystals via Flow Chemistry Technology

Continuous Synthesis of Nanocrystals via Flow Chemistry Technology

“Learning on a chip:” Microfluidics for formal and informal science education

An introduction to digital microfluidic concepts in chemistry using a macroscopic droplet generator

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