Exploring the feasibility of introducing triple artemisinin-based combination therapies in the malaria treatment policy in Vietnam

Abstract

Introduction: This study investigates the processes regarding changing malaria treatment policies in Vietnam. Moreover, it explores the feasibility of introducing triple artemisinin-based combination therapies (TACTs) in Vietnam to support the national malaria control and elimination plan. Methods Data were collected through desk review of policy documents in combination with 12 in-depth interviews with key stakeholders. Results TACTs are considered as a useful backup strategy in case future treatment failures with current artemisinin-based combination therapies (ACTs) would occur. Moreover, TACTs are also considered as a promising strategy to prevent the re-establishment of malaria. However, regulatory procedures and implementation timelines for TACTs were expected to be lengthy. Therefore, stakeholder engagement strategies should be initiated soon, stipulating the benefits of TACTs deployment. A simplified validation of registration or an import permit without registration that has been applied to the introduction of artesunate-pyronaridine was proposed to accelerate the introduction of TACTs. Global-level support through WHO recommendations and prequalification were considered critical for supporting the introduction of TACTs in Vietnam. Conclusions Appropriate approach strategies and early stakeholder engagement will be needed to accelerate the introduction of TACTs in Vietnam.