Exploring the essence of celery seeds (Apium graveolens L.): Innovations in microwave-assisted hydrodistillation for essential oil extraction using in vitro, in vivo and in silico studies

New Triazole-Isoxazole Hybrids as Antibacterial Agents: Design, Synthesis, Characterization, In Vitro, and In Silico Studies

“…The physicochemical and ADMET pharmacokinetic characteristics of the studied compound were achieved thanks to the use of pKCSM and SWISS servers. Molecular docking technology was performed using Autodock 4.2 software (Available online: , accessed on 22 May 2024), in which the responsible proteins of Escherichia coli and Pseudomonas aeruginosa strains were extracted from a protein data bank (PDB) basis with 1KZN and 4KQR codes, respectively, then converted from PDB to PDBQT format, and prepared by adding Gasteiger charges and removing water molecules [ 63 , 64 ]. Afterwards, the synthesized compound was docked to the active sites of each targeted protein, and then Discovery Studio software 2021 (Available online: , accessed on 22 May 2024) was used to visualize the intermolecular interactions produced for each complex.…”

“…Molecular docking technology was performed using Autodock 4.2 software (Available online: https:// mybiosoftware.com/autodock-4-2-3-autodocktools-1-5-6-suite-automated-docking-tools. html, accessed on 22 May 2024), in which the responsible proteins of Escherichia coli and Pseudomonas aeruginosa strains were extracted from a protein data bank (PDB) basis with 1KZN and 4KQR codes, respectively, then converted from PDB to PDBQT format, and prepared by adding Gasteiger charges and removing water molecules [63,64]. Afterwards, the synthesized compound was docked to the active sites of each targeted protein, and then Discovery Studio software 2021 (Available online: https://www.3ds.com/productsservices/biovia/products/molecular-modeling-simulation/biovia-discovery-studio, accessed on 22 May 2024) was used to visualize the intermolecular interactions produced for each complex.…”

Unveiling the Antianemic Activity, Physicochemical Aspects, Antioxidant Properties, and Mineral Profile of Petroselinum crispum L

“…Five methods to measure the antioxidant activity of PC-Ext were used: 2,2-diphenyl-1-picrylhydrazyl radical (DPPH • ), 2,2′-azino-bis (3ethylbenzothiazoline-6-sulfonic acid) radical cation-based (ABTS •+ ), ß-carotene bleaching tests (BCBT), reducing antioxidant power (RP) assays, and total antioxidant activity (TAC). All assays were determined spectrophotometrically using a UV/vis spectrophotometer. − …”

“…It is a rich source of natural antioxidants. 13 Antioxidant, 14 antibiotic, 15 antifungal, 16 neuroprotective, 17 nephroprotective, 18 antidiabetic, 19 analgesic, 20 spasmolytic, 21 antiplatelet, 22 laxative, 21 diuretic, 23 and aphrodisiac 24 are just a few of the pharmacological effects linked to parsley. Despite the extensive utilization of parsley in traditional medicine, this study was the first attempt to assess the antianemic effects of P. crispum .…”

Petroselinum crispum L., essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities: In vitro and in silico predictions

“…), Gotu kola ( Centella asiatica ), parsley ( Petroselinum crispum L.), parsnip ( Pastinaca sativa L.), Toothpick weed; khella ( Ammi visnaga (L.) Lam.) [ 5 , 6 ].…”