2017
DOI: 10.4236/jis.2017.84020
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Exploring the Effects of Gap-Penalties in Sequence-Alignment Approach to Polymorphic Virus Detection

Abstract: Antiviral software systems (AVSs) have problems in identifying polymorphic variants of viruses without explicit signatures for such variants. Alignment-based techniques from bioinformatics may provide a novel way to generate signatures from consensuses found in polymorphic variant code. We demonstrate how multiple sequence alignment supplemented with gap penalties leads to viral code signatures that generalize successfully to previously known polymorphic variants of JS. Cassandra virus and previously unknown p… Show more

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Cited by 4 publications
(5 citation statements)
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“…After conversion (Step-4), six discrete pairwise alignments (Step-5a) were first conducted (sequence 1 with sequence 2, sequence 3 with sequence 4, etc. [13]) was used during the processes of pairwise sequence alignment.…”
Section: Discussionmentioning
confidence: 99%
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“…After conversion (Step-4), six discrete pairwise alignments (Step-5a) were first conducted (sequence 1 with sequence 2, sequence 3 with sequence 4, etc. [13]) was used during the processes of pairwise sequence alignment.…”
Section: Discussionmentioning
confidence: 99%
“…More details referring to the steps involved in this experiment can be found in the previous work [13] and Figure A1. Our method for Experiment I consists of six steps (see Figure A1).…”
Section: Conflicts Of Interestmentioning
confidence: 99%
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