Exploring the effect of sintering temperature on naturally derived hydroxyapatite for bio-medical applications

S, Aarthy; Thenmuhil, D.; Dharunya, G; Manohar, P.

doi:10.1007/s10856-019-6219-9

Cited by 29 publications

(21 citation statements)

References 29 publications

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“…Rosa et al (2000) while investigating the effect of powder processing and sintering conditions on the porosity of experimental hydroxyapatite scaffolds, demonstrated that parameters investigated (either temperature and load) were inversely correlated to porosity size. Aarthy et al (2019) while exploring the effect of sintering temperatures on the properties of naturally derived hydroxyapatite materials, have shown that bioactivity was proportionally correlated to sintering temperature where higher temperatures resulted in materials displaying stronger bioactivity properties. Other studies suggest that high-temperature (> 900C) treatments may negatively affect the crystalline structure of hydroxyapatite and their biological properties (Figueiredo et al, 2010;Lopez-Heredia et al, 2011), which may be used to partially explain the variability associated with the osteoconductive and osteoinductive properties of commercially available products.…”

Section: Discussionmentioning

confidence: 99%

In vivo transdifferentiation, osteoconductive and osteoinductive properties of experimental water-soluble organo-biomaterials – A Pilot Study

Crivellaro

Spada

Judachesci

et al. 2021

RSD

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Inorganic bovine bone matrix (IBBM) is a biomaterial with proven osteoconductive functionalities. The objective of this study was to assess the in vivo bone regeneration functionalities of IBBM modified or not by an experimental MOE in sheep. MOE synthesis was performed by suspending nacre particles (0.05 g, diameters < 0.01 mm) in anhydrous acetic acid (pH 7, 5 mL, 25°C, 72 hours) using magnetic stirring. Polyethylene carriers (d= 5.0 mm, l= 10.0 mm, open ends) of negative control (sham) or experimental groups (IBBM or MOE-modified IBBM) were placed (n=3 conditions /animal; intramuscularly) adjacent to the lower spine of adult sheep (8 animals, » 45 Kg, 2 years old). Tissues were harvested (at 3 or 6 months) after implantation in preparation for histological (H), morphometrical (MM) and immunohistochemical analyses (IH; Wnt-3a, CD34, Vimentin and PREF-1). MM data were tested for normality and variance homogeneity using the Shapiro-Wilk and Levene tests, and Mann Whitney and Kruskal-Wallis, respectively. IM data were analyzed using two-way ANOVA and Tukey tests. Differences (p < 0.05) were observed between experimental groups (IBBM and IBBM+MOE at both 3 and 6 months) and controls (sham) for total area; Differences were not found for presence of remnant particles among experimental groups. The highest formation of bone was observed with IBBM+MOE (6-months). No differences (p > 0.05) were found on IM analysis (CD34, Vimentin, PREF-1, Wnt3a). Results indicated that experimental materials (IBBM+MOE) display promising functionalities. Additional studies are necessary to define biomaterials’ longitudinal effects and long-term biocompatibility properties.

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Section: Discussionmentioning

confidence: 99%

In vivo transdifferentiation, osteoconductive and osteoinductive properties of experimental water-soluble organo-biomaterials – A Pilot Study

Crivellaro

Spada

Judachesci

et al. 2021

RSD

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“…Bio-ceramics are brittle and difficult to shape for implantation. HA is the main component of bone, and it can be ideally adapted as bone graft replacement, it is difficult to control its degradation rate (Aarthy et al , 2019). Scaffolds produced from mixtures of TCP or TTCP have comparable cell growth and proliferation as the scaffolds (Detsch et al , 2011; Gao et al , 2014).…”

Section: Three-dimensional Printing Technologies and Materialsmentioning

confidence: 99%

3D printing in tissue engineering: a state of the art review of technologies and biomaterials

Poomathi

Singh

Prakash

et al. 2020

RPJ

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Purpose In the past decade, three-dimensional (3D) printing has gained attention in areas such as medicine, engineering, manufacturing art and most recently in education. In biomedical, the development of a wide range of biomaterials has catalysed the considerable role of 3D printing (3DP), where it functions as synthetic frameworks in the form of scaffolds, constructs or matrices. The purpose of this paper is to present the state-of-the-art literature coverage of 3DP applications in tissue engineering (such as customized scaffoldings and organs, and regenerative medicine). Design/methodology/approach This review focusses on various 3DP techniques and biomaterials for tissue engineering (TE) applications. The literature reviewed in the manuscript has been collected from various journal search engines including Google Scholar, Research Gate, Academia, PubMed, Scopus, EMBASE, Cochrane Library and Web of Science. The keywords that have been selected for the searches were 3 D printing, tissue engineering, scaffoldings, organs, regenerative medicine, biomaterials, standards, applications and future directions. Further, the sub-classifications of the keyword, wherever possible, have been used as sectioned/sub-sectioned in the manuscript. Findings 3DP techniques have many applications in biomedical and TE (B-TE), as covered in the literature. Customized structures for B-TE applications are easy and cost-effective to manufacture through 3DP, whereas on many occasions, conventional technologies generally become incompatible. For this, this new class of manufacturing must be explored to further capabilities for many potential applications. Originality/value This review paper presents a comprehensive study of the various types of 3DP technologies in the light of their possible B-TE application as well as provides a future roadmap.

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“…According with was described by Aarthy et al [11], thirty-nine teeth were dehydrated in 100 mL of 99.8% absolute ethyl alcohol (NEON, SP, Brazil) with 100 mL of distilled water forming a hydro alcoholic solution. The teeth were placed in a distillation flask (Laborglass, SP, Brazil) that was coupled to a ball condenser through a universal support (Laborglass, SP, Brazil) using a metallic claw (Laborglass, SP, Brazil) and muffle (Laborglass, SP, Brazil).…”

Section: Extraction Of Hapmentioning

confidence: 99%

“…In the last years, researchers have synthesized hydroxyapatite by chemical methods. There are many methods available, such as dry methods, wet methods, high temperature processes, synthesis from biogenic sources and combination procedures [9][10][11]. Nevertheless, hydroxyapatite is brittle, and researchers are still developing a method that prepares the bioactive hydroxyapatite with excellent mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Microleakage of Class I cavities restored with hydroxyapatite and glass ionomer cement

Caetano¹,

Steck²,

Mohieddine³

et al. 2020

IJAERS

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The aim was to evaluate the use of hydroxyapatite powder (HDX) obtained from human teeth as a material to filled occlusal cavities compared with glass ionomer cement (GIC) through the microleakage analysis. Methods: Sixty-one permanent teeth were selected. Thirty-nine samples were used to obtain the hydroxyapatite powder and 22 used to obtain specimens for microleakage analysis. The teeth were sterilized. Two standardized Class I cavities were performed on the occlusal surface of each tooth. The specimens were randomly distributed in two groups (n = 11) GIC and HDX. The same sample received in occlusal cavities GIC and HDX restorations. After 24 hours 11 samples were immersed in broth containing S.mutans (ATCC 25175) and 5% methylene blue dye (MB + S. mutans) and the remaining 11 samples were immersed in 5% MB. Samples were sectioned mid-distally and dye leakage was assessed by three calibrated examiners. Results: The data were analyzed with Kruskall-Wallis test. There was no difference between GIC and HDX (P>0.05) and between the MB and MB with S. mutans (P>0.05). Conclusion: Within the limitations of this in vitro study it can be concluded that hydroxyapatite may be an alternative as a restorative material.

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Exploring the effect of sintering temperature on naturally derived hydroxyapatite for bio-medical applications

Cited by 29 publications

References 29 publications

In vivo transdifferentiation, osteoconductive and osteoinductive properties of experimental water-soluble organo-biomaterials – A Pilot Study

In vivo transdifferentiation, osteoconductive and osteoinductive properties of experimental water-soluble organo-biomaterials – A Pilot Study

3D printing in tissue engineering: a state of the art review of technologies and biomaterials

Microleakage of Class I cavities restored with hydroxyapatite and glass ionomer cement

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