Exploring the effect of previous inactivated influenza vaccination on seasonal influenza vaccine effectiveness against medically attended influenza: Results of the European I‐<scp>MOVE</scp> multicentre test‐negative case‐control study, 2011/2012‐2016/2017

Valenciano, Marta; Kissling, Esther; Larrauri, Amparo; Nunes, Baltazar; Pițigoi, Daniela; O’Donnell, Joan; Reuß, Annicka; Horváth, J; Paradowska-Stankiewicz, Iwona; Rizzo, Caterina; Falchi, Alessandra; Daviaud, Isabelle; Brytting, Mia; Meijer, Adam; Kaić, Bernard; Gherasim, Alin; Machado, Ausenda; Lina, Bruno; Domegan, Lisa; Schweiger, Brunhilde; Ferenczi, Annamária; Korczyńska, Monika Roberta; Bella, Antonino; Vilcu, Ana‐Maria; Mosnier, Anne; Zakikhany, Katherina; Lange, Marit de; Filipovićović, Sanja Kurečić; Johansen, Kari; Moren, Alain

doi:10.1111/irv.12562

Cited by 26 publications

(30 citation statements)

References 32 publications

(43 reference statements)

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“…Influenza vaccination was associated with a lower risk of being IV-positive, in concordance with the influenza vaccine effectiveness estimated for these two seasons in Europe (33%, 95% CI 10e51 against A (H1N1)pdm09 viruses in 2015/16; 20%, 95% CI e14 to 43 against B viruses in 2015/16; 21%, 95% CI 6e34 against A (H3N2) viruses in 2016/17) [24].…”

Section: Discussionsupporting

confidence: 79%

Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care

Souty

Masse

Valette

et al. 2019

Clinical Microbiology and Infection

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a b s t r a c tObjectives: We aimed to identify patients' clinical characteristics associated with respiratory viruses identified among patients presenting with influenza-like illness (ILI). Methods: A sample of patients of all ages presenting with ILI was included by physicians of the French Sentinelles network during two seasons (2015/16 and 2016/17). Nasopharyngeal samples were tested for the presence of influenza virus (IV), respiratory syncytial virus (RSV), human rhinovirus (HRV) and human metapneumovirus (HMPV). Patients' characteristics associated with each of the four virus classes were studied using multivariate logistic regressions. Results: A total of 5859 individuals were included in the study: 48.0% tested positive for IV, 7.9% for HRV, 7.5% for RSV and 4.1% for HMPV. Cough was associated with IV (OR 2.14, 95% CI 1.81e2.52) RSV (OR 2.52, 95% CI 1.75e3.74) and HMPV detection (OR 2.15, 95% CI 1.40e3.45). Rhinorrhoea was associated mainly with HRV detection (OR 1.75, 95% CI 1.34e2.32). Headache was associated with IV detection (OR 1.75, 95% CI 1.34e2.32), whereas absence of headache was associated with RSV and HMPV detection. Dyspnoea was associated with RSV detection (OR 2.33, 95% CI 1.73e3.12) and absence of dyspnoea with IV detection. Conjunctivitis was associated with IV detection (OR 1.27, 95% CI 1.08e1.50). Some associations were observed only in children: dyspnoea and cough with RSV detection (age <5 years), conjunctivitis with IV detection (age <15 years). Period of onset of symptoms differed among aetiological diagnoses. Seasonal influenza vaccination decreased the risk of IV detection (OR, 0.67, 95% CI 0.51e0.86).Conclusions: This study allowed the identification of symptoms associated with several viral aetiologies in patients with ILI. A proper knowledge and understanding of these clinical signs may improve the medical management of patients. C. Souty, Clin Microbiol Infect 2019;25:1147

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Section: Discussionsupporting

confidence: 79%

Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care

Souty

Masse

Valette

et al. 2019

Clinical Microbiology and Infection

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“…While reduced VE from repeated vaccination has been reported previously [13,25], this has not been consistently found [11,12]. The antigenic distance hypothesis is one potential explanation for reduced VE; if the vaccine strains for the current season and prior season are similar but the current season's vaccine strain is distinct from the current epidemic strain, negative interference leading to reduced VE for the current season may result [7].…”

Section: Discussionmentioning

confidence: 91%

“…Vaccine responses may be enhanced with recent prior infection [27], such that those who were vaccinated repeatedly may appear to have lower VE. However, measuring immunity arising from previous infection is challenging [11]. In addition, while pooling of multiple seasons can increase statistical power, it can mask important variation at the individual season level [14].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the antigenic distance hypothesis put forth by Smith et al, negative or positive interference can result from prior season vaccination depending on differences in the antigenic distances between prior and current vaccine strains and the current epidemic strain [7]. Most studies to date incorporated only a single previous season when examining the impact of repeated vaccination [8][9][10][11][12][13]. Meta-analyses of these studies found substantial heterogeneity in repeated vaccination effects [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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The impact of repeated vaccination using 10-year vaccination history on protection against influenza in older adults: a test-negative design study across the 2010/11 to 2015/16 influenza seasons in Ontario, Canada

et al. 2020

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Introduction Annual influenza vaccination is recommended for older adults, but evidence regarding the impact of repeated vaccination has been inconclusive. Aim We investigated vaccine effectiveness (VE) against laboratory-confirmed influenza and the impact of repeated vaccination over 10 previous seasons on current season VE among older adults. Methods We conducted an observational test-negative study in community-dwelling adults aged > 65 years in Ontario, Canada for the 2010/11 to 2015/16 seasons by linking laboratory and health administrative data. We estimated VE using multivariable logistic regression. We assessed the impact of repeated vaccination by stratifying by previous vaccination history. Results We included 58,304 testing episodes for respiratory viruses, with 11,496 (20%) testing positive for influenza and 31,004 (53%) vaccinated. Adjusted VE against laboratory-confirmed influenza for the six seasons combined was 21% (95% confidence interval (CI): 18 to 24%). Patients who were vaccinated in the current season, but had received no vaccinations in the previous 10 seasons, had higher current season VE (34%; 95%CI: 9 to 52%) than patients who had received 1–3 (26%; 95%CI: 13 to 37%), 4–6 (24%; 95%CI: 15 to 33%), 7–8 (13%; 95%CI: 2 to 22%), or 9–10 (7%; 95%CI: −4 to 16%) vaccinations (trend test p = 0.001). All estimates were higher after correcting for misclassification of current season vaccination status. For patients who were not vaccinated in the current season, residual protection rose significantly with increasing numbers of vaccinations received previously. Conclusions Although VE appeared to decrease with increasing numbers of previous vaccinations, current season vaccination likely provides some protection against influenza regardless of the number of vaccinations received over the previous 10 influenza seasons.

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“…7 which were below 50%, 8,9 as they have been for almost a decade. [10][11][12][13][14][15][16][17] A recent systematic review of studies using the test-negative design estimated a pooled IVE of 24% (95% CI: −6 to 45) against influenza A(H3N2) in older adults (>60 years) for the consecutive seasons 2004-2015. 18 20 This IVE is lower, however, than the 52% seen in 2015-16, when there was also a lineage mismatch for B…”

Section: Influenza Bmentioning

confidence: 99%

Vaccine effectiveness against influenza A(H3N2) and B among laboratory‐confirmed, hospitalised older adults, Europe, 2017‐18: A season of B lineage mismatched to the trivalent vaccine

Rose¹,

Kissling²,

Gherasim

et al. 2020

Influenza Resp Viruses

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Background: Influenza A(H3N2), A(H1N1)pdm09 and B viruses co-circulated in Europe in 2017-18, predominated by influenza B. WHO-recommended, trivalent vaccine components were lineage-mismatched for B. The I-MOVE hospital network measured 2017-18 seasonal influenza vaccine effectiveness (IVE) against influenza A(H3N2) and B among hospitalised patients (≥65 years) in Europe.Methods: Following the same generic protocol for test-negative design, hospital teams in nine countries swabbed patients ≥65 years with recent onset (≤7 days) severe acute respiratory infection (SARI), collecting information on demographics, vaccination status and underlying conditions. Cases were RT-PCR positive for influenza A(H3N2) or B; controls: negative for any influenza. "Vaccinated" patients had SARI onset >14 days after vaccination. We measured pooled IVE against influenza, adjusted for study site, age, sex, onset date and chronic conditions. Results:We included 3483 patients: 376 influenza A(H3N2) and 928 B cases, and 2028 controls. Most (>99%) vaccinated patients received the B lineage-mismatched trivalent vaccine. IVE against influenza A(H3N2) was 24% (95% CI: 2 to 40); 35% (95% CI: 6 to 55) in 65-to 79-year-olds and 14% (95% CI: −22 to 39) in ≥80-year-olds.Against influenza B, IVE was 30% (95% CI: 16 to 41); 37% (95% CI: 19 to 51) in 65-to 79-year-olds and 19% (95% CI: −7 to 38) in ≥80-year-olds. | 303 ROSE Et al.Conclusions: IVE against influenza B was similar to A(H3N2) in hospitalised older adults, despite trivalent vaccine and circulating B lineage mismatch, suggesting some cross-protection. IVE was lower in those ≥80 than 65-79 years. We reinforce the importance of influenza vaccination in older adults as, even with a poorly matched vaccine, it still protects one in three to four of this population from severe influenza. K E Y W O R D SEurope, hospital, influenza, older adults, test-negative design, vaccine effectiveness

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Exploring the effect of previous inactivated influenza vaccination on seasonal influenza vaccine effectiveness against medically attended influenza: Results of the European I‐MOVE multicentre test‐negative case‐control study, 2011/2012‐2016/2017

Cited by 26 publications

References 32 publications

Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care

Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care

The impact of repeated vaccination using 10-year vaccination history on protection against influenza in older adults: a test-negative design study across the 2010/11 to 2015/16 influenza seasons in Ontario, Canada

Vaccine effectiveness against influenza A(H3N2) and B among laboratory‐confirmed, hospitalised older adults, Europe, 2017‐18: A season of B lineage mismatched to the trivalent vaccine

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