Exploring the dynamics of toxigenic environmental Vibrio mimicus and its comparative analysis with Vibrio cholerae of the southern Gangetic delta

Halder, Madhumanti; Saha, Suvajit; Mookerjee, Subham; Palit, A.

doi:10.1007/s00203-022-03028-z

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Additionally, V. mimicus can endanger human health by contamination food, water, and wounds (Yang et al, 2021 ), leading to life-threatening cholera-like diarrhea and septicemia. V. mimicus shares a remarkably similar genome and ecological niche with Vibrio cholerae , displaying adaptability to the human host (Hernandez-Robles et al, 2021 ), thereby positioning itself as a potential pandemic pathogen (Halder et al, 2022 ). Antibiotics are currently the most critical method of combating bacterial diseases.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome reveals the role of the htpG gene in mediating antibiotic resistance through cell envelope modulation in Vibrio mimicus SCCF01

Qin,

Peng,

Feng

et al. 2024

Front. Microbiol.

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HtpG, a bacterial homolog of the eukaryotic 90 kDa heat-shock protein (Hsp90), represents the simplest member of the heat shock protein family. While the significance of Hsp90 in fungal and cancer drug resistance has been confirmed, the role of HtpG in bacterial antibiotic resistance remains largely unexplored. This research aims to investigate the impact of the htpG gene on antibiotic resistance in Vibrio mimicus. Through the creation of htpG gene deletion and complementation strains, we have uncovered the essential role of htpG in regulating the structural integrity of the bacterial cell envelope. Our transcriptomics analysis demonstrates that the deletion of htpG increases the sensitivity of V. mimicus to antimicrobial peptides, primarily due to upregulated lipopolysaccharide synthesis, reduced glycerophospholipid content, and weakened efflux pumps activity. Conversely, reduced sensitivity to β-lactam antibiotics in the ΔhtpG strain results from decreased peptidoglycan synthesis and dysregulated peptidoglycan recycling and regulation. Further exploration of specific pathway components is essential for a comprehensive understanding of htpG-mediated resistance mechanisms, aiding in the development of antimicrobial agents. To our knowledge, this is the first effort to explore the relationship between htpG and drug resistance in bacteria.

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Section: Introductionmentioning

confidence: 99%

Transcriptome reveals the role of the htpG gene in mediating antibiotic resistance through cell envelope modulation in Vibrio mimicus SCCF01

Qin,

Peng,

Feng

et al. 2024

Front. Microbiol.

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“…Recent scientific reports indicate that V. vulnificus is expanding its range of occurrence on the US east coast as a result of ongoing climate change and could become a serious epidemiological problem. Studies show that the number of infections caused by this pathogen has increased dramatically from 10 to 80 cases per year [15,26]. Rapidly progressive tissue necrosis can be caused by infection with V. damsela, which was most often isolated from wounds in contact with contaminated, salty seawater.…”

Section: Damsela)mentioning

confidence: 99%

Properties and Pathogenicity of the Vibrio Bacilli

Tarasiuk¹,

Weiner²

2023

hpc

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Non-O1/O139 Vibrio cholerae causes severe intestinal disease in bullfrogs (Rana catesbeiana)

Liao,

Wei,

Liu

et al. 2023

Animal Diseases

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Bullfrogs (Rana catesbeiana) are amphibians with high economic value, but in recent years, bullfrog farming has encountered serious threats of bacterial diseases, and the “bullfrog economy” is facing a continuous decline. In this study, the dominant strain was isolated from diseased bullfrogs in a bullfrog farm in Nanning, Guangxi, and based on its morphological, physiological, and biochemical characteristics and analysis of 16S rRNA gene sequences, the strain was identified as a non-O1/O139 group Vibrio cholerae and named TC1. Three virulence factors were identified in this strain, including hemolysin, outer membrane protein, and toxin-coregulated pili. Drug susceptibility testing showed that the strain resisted gentamicin, florfenicol, nitrofural, oxytetracycline, neomycin, penicillin, amoxicillin, doxycycline, and sulfamonomethoxine. The results of artificial infection experiments showed that TC1 caused serious pathologies such as abdominal swelling and anal prolapse in bullfrogs, especially severe intestinal bleeding. Histopathological observations revealed that the bullfrog intestine exhibited obvious pathological lesions. These results provide an essential epidemiological basis for controlling V. cholerae infections in aquatic animals and demonstrate the promise of bullfrogs as an amphibian model for studying the pathogenesis of V. cholerae.

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Exploring the dynamics of toxigenic environmental Vibrio mimicus and its comparative analysis with Vibrio cholerae of the southern Gangetic delta

Cited by 3 publications

References 46 publications

Transcriptome reveals the role of the htpG gene in mediating antibiotic resistance through cell envelope modulation in Vibrio mimicus SCCF01

Transcriptome reveals the role of the htpG gene in mediating antibiotic resistance through cell envelope modulation in Vibrio mimicus SCCF01

Properties and Pathogenicity of the Vibrio Bacilli

Non-O1/O139 Vibrio cholerae causes severe intestinal disease in bullfrogs (Rana catesbeiana)

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