Exploring the dynamics and interactions of the N-myc transactivation domain through solution NMR
Ewa Rejnowicz,
Matthew Batchelor,
Eoin Leen
et al.
Abstract:The myc family of proteins (c-, N- and L-myc) are transcription factors (TFs) responsible for maintaining the proliferative program in cells. They consist of a C-terminal domain that mediates heterodimerisation with Max and DNA binding, and an N-terminal disordered region culminating in the transactivation domain (TAD). The TAD participates in many protein-protein interactions, notably with kinases that promote stability (Aurora-A) or degradation (ERK1, GSK3) via the ubiquitin-proteasome system. Structural cha… Show more
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