This study empirically analyzes the effects of four lifestyles of office workers (work and life balance, you only live once (YOLO), minimal life, and staycation), which have been changed during the COVID-19 pandemic, on organizational effectiveness (measured by job satisfaction, organizational commitment, and organizational citizenship behavior). A questionnaire survey was conducted over four months through a global research firm. In total, 649 valid questionnaires were collected. A structural equation model analysis was performed on valid samples using SmartPLS statistics. The results were as follows: (1) Work and life balance, YOLO, and minimal life had a statistically significant positive effect on job satisfaction. (2) Minimal life had a statistically significant positive effect on organizational commitment. (3) Work and life balance, and staycation had statistically significant positive effects on organizational citizenship behavior. (4) Job satisfaction had a statistically significant positive effect on organizational commitment. (5) Job satisfaction and organizational commitment had a statistically significant positive effect on organizational citizenship behavior. This is the first empirical study to focus on four lifestyles (work–life balance, YOLO, minimal life, and staycation). The results show that job satisfaction was affected the most by YOLO,’ that organizational commitment was affected the most by minimal life, and that organizational citizenship behavior was affected the most by work–life balance.