Exploring the cytotoxic potential of biflavones of Araucaria cunninghamii: Precise identification combined by LC‐HRMS‐metabolomics and database mining, targeted isolation, network pharmacology, in vitro cytotoxicity, and docking studies
Bharat Sahu,
Sanheeta Chakrabarty,
Vaishali Saini
et al.
Abstract:The leaves of Araucaria cunninghamii are known to be nonedible and toxic. Previous studies have identified biflavones in various Araucaria species. This study aimed to investigate the in vitro cytotoxicity of the isolated compounds from Araucaria cunninghamii after metabolomics and network pharmacological analysis. Methanol extract of Araucaria cunninghamii leaves was subjected to bioassay‐guided fractionation. The active fraction was analyzed using LC‐HRMS, through strategic database mining, by comparing the … Show more
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