Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues

Sundar Rajan, Vinoth; Wypijewska del Nogal, Anna; Levin, Sune; Wilhelmsson, L. Marcus; Westerlund, Fredrik

doi:10.1039/d3nr04110g

Nanoscale

2024

DOI: 10.1039/d3nr04110g

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Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues

Vinoth Sundar Rajan,

Anna Wypijewska del Nogal,

Sune Levin

et al.

Abstract: We characterize the stability, conformational dynamics, (un)folding pathways, as well as identify a promising drug–target site within the SL4 hairpin of the SARS-CoV-2 by combining base analogues and optical tweezers.

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Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues

Abstract: We characterize the stability, conformational dynamics, (un)folding pathways, as well as identify a promising drug–target site within the SL4 hairpin of the SARS-CoV-2 by combining base analogues and optical tweezers.

Cited by 0 publications

References 50 publications

No citations

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