Exploring the complexity of systemic sclerosis etiology by trio whole genome sequencing
Hongzheng Dai,
Shamika Ketkar,
Taotao Tan
et al.
Abstract:Systemic sclerosis (SSc) is a heterogeneous rare autoimmune fibrosing disorder affecting connective tissue. The etiology of systemic sclerosis is largely unknown and many genes have been suggested as susceptibility loci of modest impact by genome-wide association study (GWAS). Multiple factors can contribute to the pathological process of the disease, which makes it more difficult to identify possible disease-causing genetic alterations. In this study, we have applied whole genome sequencing (WGS) in 101 index… Show more
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