Exploring the Complex Relationship between Diabetes and Cardiovascular Complications: Understanding Diabetic Cardiomyopathy and Promising Therapies

Ghosh, Nilanjan; Chacko, Leena; Bhattacharya, Hiranmoy; Vallamkondu, Jayalakshmi; Nag, Sagnik; Dey, Abhijit; Karmakar, Tanushree; Reddy, P. Hemachandra; Kandimalla, Ramesh; Dewanjee, Saikat

doi:10.3390/biomedicines11041126

Cited by 18 publications

(8 citation statements)

References 182 publications

(197 reference statements)

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“…The role of CADD in cardiovascular diseases : Cardiovascular diseases (CVD) are considered the first cause of death globally 178 . It is common to have significant coronary heart disease, myocardial ischemia and hypertension, as well as diabetes-related complications 179 . Early scientists used CADD technology applied to cardiovascular disease research and successfully discovered the ACE1 inhibitor captopril 124 .…”

Section: Discussionmentioning

confidence: 99%

Current perspectives and trend of computer-aided drug design: a review and bibliometric analysis

Wu,

Chen,

Wang

et al. 2024

International Journal of Surgery

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Aim: Computer-aided drug design (CADD) is a drug design technique for computing ligand‒receptor interactions and is involved in various stages of drug development. To better grasp the frontiers and hotspots of CADD, we conducted a review analysis through bibliometrics. Methods: A systematic review of studies published between 2000 and July 20, 2023 was conducted following the PRISMA guidelines. Literature on CADD was selected from the Web of Science Core Collection. General information, publications, output trends, countries/regions, institutions, journals, keywords, and influential authors were visually analysed using software such as Excel, VOSviewer, RStudio, and CiteSpace. Results: A total of 2,031 publications were included. These publications primarily originated from 99 countries or regions, led by the U.S. and China. Among the contributors, MacKerell AD had the highest number of articles and greatest influence. The Journal of Medicinal Chemistry was the most cited journal, whereas the Journal of Chemical Information and Modeling had the highest number of publications. Conclusions: Influential authors in the field were identified. Current research shows active collaboration between countries, institutions, and companies. CADD technologies such as homology modelling, pharmacophore modelling, quantitative conformational relationships, molecular docking, molecular dynamics simulation, binding free energy prediction, and high-throughput virtual screening can effectively improve the efficiency of new drug discovery. Artificial intelligence-assisted drug design and screening based on CADD represent key topics direction for future development. Furthermore, this paper will be helpful for better understanding the frontiers and hotspots of CADD.

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Section: Discussionmentioning

confidence: 99%

Current perspectives and trend of computer-aided drug design: a review and bibliometric analysis

Wu,

Chen,

Wang

et al. 2024

International Journal of Surgery

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“…In cases of MCR (Mucocutaneous Candidiasis and Reticuloendotheliosis) and diabetes, fungal infections primarily affect the rhino-orbital-cerebral region and the cutaneous and pulmonary areas. In diabetic patients, the invasive fungal infection shows significant aggressive signs, including facial pain and purulent nasal discharges ( 60 , 61 ). Thus, the complications associated with diabetes related mycosis are challenging to address via conventional antiviral therapies ( 62 ).…”

Section: Risk Factors For Individuals Prone To Fungal Diseasementioning

confidence: 99%

Virulence traits and novel drug delivery strategies for mucormycosis post-COVID-19: a comprehensive review

Faiyazuddin,

Sophia,

Ashique

et al. 2023

Front. Immunol.

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The outbreak of a fatal black fungus infection after the resurgence of the cadaverous COVID-19 has exhorted scientists worldwide to develop a nutshell by repurposing or designing new formulations to address the crisis. Patients expressing COVID-19 are more susceptible to Mucormycosis (MCR) and thus fall easy prey to decease accounting for this global threat. Their mortality rates range around 32-70% depending on the organs affected and grow even higher despite the treatment. The many contemporary recommendations strongly advise using liposomal amphotericin B and surgery as first-line therapy whenever practicable. MCR is a dangerous infection that requires an antifungal drug administration on appropriate prescription, typically one of the following: Amphotericin B, Posaconazole, or Isavuconazole since the fungi that cause MCR are resistant to other medications like fluconazole, voriconazole, and echinocandins. Amphotericin B and Posaconazole are administered through veins (intravenously), and isavuconazole by mouth (orally). From last several years so many compounds are developed against invasive fungal disease but only few of them are able to induce effective treatment against the micorals. Adjuvant medicines, more particularly, are difficult to assess without prospective randomized controlled investigations, which are challenging to conduct given the lower incidence and higher mortality from Mucormycosis. The present analysis provides insight into pathogenesis, epidemiology, clinical manifestations, underlying fungal virulence, and growth mechanisms. In addition, current therapy for MCR in Post Covid-19 individuals includes conventional and novel nano-based advanced management systems for procuring against deadly fungal infection. The study urges involving nanomedicine to prevent fungal growth at the commencement of infection, delay the progression, and mitigate fatality risk.

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“…43 The NF-κB response triggered by lipopolysaccharide in monocytes and dendritic cells serves as a phenotypic characteristic and a potential indicator of pathogenic processes in human T1D. 47 In animal murine models of T1D, it has been observed that TNF receptor-associated factor 6 (TRAF6) plays a mediating role in endothelial damage induced by high glucose levels, and this process is governed by signaling pathways involving NF-κB and AP-1. 48,49 In human monocytic lymphocytes, miRNA-146a, a transcriptional product of the LOC285628 gene situated on the 5th chromosome, is responsive to lipopolysaccharide (LPS) stimulation.…”

Section: Type I Diabetesmentioning

confidence: 99%

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Nag,

Mitra,

Tripathi

et al. 2023

Immunity Inflam & Disease

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BackgroundAutoimmune diseases (AD) are severe pathophysiological ailments that are stimulated by an exaggerated immunogenic response towards self‐antigens, which can cause systemic or site‐specific organ damage. An array of complex genetic and epigenetic facets majorly contributes to the progression of AD, thus providing significant insight into the regulatory mechanism of microRNA (miRNA). miRNAs are short, non‐coding RNAs that have been identified as essential contributors to the post‐transcriptional regulation of host genome expression and as crucial regulators of a myriad of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immune cell development.AimsThis article tends to deliberate and conceptualize the brief pathogenesis and pertinent epigenetic regulatory mechanism as well as miRNA networks majorly affecting five different ADs namely rheumatoid arthritis (RA), type 1 diabetes, multiple sclerosis (MS), systemic lupus erythematosus (SLE) and inflammatory bowel disorder (IBD) thereby providing novel miRNA‐based theranostic interventions.Results & DiscussionPertaining to the differential expression of miRNA attributed in target tissues and cellular bodies of innate and adaptive immunity, a paradigm of scientific expeditions suggests an optimistic correlation between immunogenic dysfunction and miRNA alterations.ConclusionTherefore, it is not astonishing that dysregulations in miRNA expression patterns are now recognized in a wide spectrum of disorders, establishing themselves as potential biomarkers and therapeutic targets. Owing to its theranostic potencies, miRNA targets have been widely utilized in the development of biosensors and other therapeutic molecules originating from the same.

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Exploring the Complex Relationship between Diabetes and Cardiovascular Complications: Understanding Diabetic Cardiomyopathy and Promising Therapies

Cited by 18 publications

References 182 publications

Current perspectives and trend of computer-aided drug design: a review and bibliometric analysis

Current perspectives and trend of computer-aided drug design: a review and bibliometric analysis

Virulence traits and novel drug delivery strategies for mucormycosis post-COVID-19: a comprehensive review

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

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