Burn injuries are associated with high morbidity and fatality. Severe burns are complicated by an inflammatory and immunological response, metabolic abnormalities, and distributive shock that can cause multiple organ failure and be difficult to manage. Burns pose a considerate impact on patient's quality of life, mental and physical health. A burn injury frequently necessitates a lifelong healing procedure. Changes in survivors' mobility, appearance, and capacity to carry out activities of daily living have an influence on them. Burn injury trauma can persist for years, giving survivors anxiety and making daily life more difficult. Evidence points to substance-abuse disorders and psychiatric comorbidities as having an effect on social reintegration postburn, in addition to damage severity and physical comorbidities. Additionally, increased prevalence of substance addiction and psychiatric illnesses are reported among burn patients and survivors. Long-term and frequently complex hospital care as well as prolonged and unsuccessful postburn rehabilitation have been linked to substance misuse and psychiatric illnesses. Psychiatric rehabilitation is impacted by the stigma attached to burns, substance abuse, mental illness, and pain. Burn patients are commonly prescribed opioids in clinical practice for the management of pain. However, long-term opioid use, albeit beneficial, leads to opioid dependence and may also be associated with other mental health problems. Psychological assessments of burn survivors can also help in prevention of substance abuse. The purpose of this research is to review the available information about relationship of substance abuse and living situation of burn survivors.