Polyethylene (PE) contributes largely to plastic wastes that exist in aquatic environments as a consequence of its widespread use. To address its low degradability, pro-oxidant fillers are incorporated into its polymer matrix, making it oxo-biodegradable. In this study, films from transparent oxo-biodegradable polyethylene plastic bags were immersed in deionized water at 50°C for 35 days. Indicators of water quality: pH, oxidation-reduction potential, turbidity, and total dissolved solids (TDS), were monitored every 7 days. It was observed that pH initially rises and then slowly decreases with time, oxidation-reduction potential decreases below the control, and turbidity and total dissolved solids both increase steadily with time. Moreover, films of smaller thickness lead to a dramatic increase in turbidity and TDS. The results imply that degrading oxo-biodegradable PE plastic bags result to significant reduction of water quality.