Exploring the Binding Affinity and Molecular Interactions: A Comprehensive Study on the Molecular Docking of Benzimidazole Derivatives
Akshada A Koparde,
Rutuja S Patil,
Shraddha D Patil
et al.
Abstract:The aim of this research work was to study the comparative binding affinities of benzimidazole derivatives (2-methyl-1H-benzo[d]imidazole and 2-phenyl benzimidazole) against COX, LOX, and estrogen receptor. Benzimidazole stands as a vital heterocyclic aromatic organic molecule, playing a pivotal role in medicinal chemistry due to its essential pharmacophore and structural significance. The three-dimensional structures of COX, LOX, and the estrogen receptor were sourced from the PDB database. Concurrently, the … Show more
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