Exploring the atmosphere By G. M. B. Dobson. Pp. xi + 188. Clarendon Press; Oxford University Press, London. 1963. 21s. net

Mason, Bruce B.

doi:10.1016/0160-9327(63)90076-0

Cited by 1 publication

(1 citation statement)

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“…In this study, we followed this “biological path” extensively by looking into the single–fish behaviour as well as the bone structures of the fish. On the other hand, we expect the knockout of the col11a2 gene to trigger a larger response in a larger group, since the discontinuous nature of the dynamical order–disorder transition [17, 28] will be blurred out in a small group, as a consequence of the finite-size effect [64]. However, performing such an experiment with a large group of mutant fish is challenging, as mutants display a relatively high mortality rate.…”

Section: Discussionmentioning

confidence: 99%

Tuning Collective Behaviour in Zebrafish with Genetic Modification

Yang,

Kawafi,

Tong

et al. 2024

Preprint

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Zebrafish collective behaviour is widely used to assess their physical and mental state, serving as a valuable tool to assess the impact of ageing, disease genetics, and the effect of drugs. The essence of these macroscopic phenomena can be represented by active matter models, where the individuals are abstracted as interactive self-propelling agents. The behaviour of these agents depends on a set of parameters in a manner reminiscent of those between the constituents of physical systems. In a few cases, the system may be controlled at the level of the individual constituents such as the interactions between colloidal particles, or the enzymatic behaviour of de novo proteins. Usually, however, while the collective behaviour may be influenced by environmental factors, it typically cannot be changed at will. Here, we challenge this scenario in a biological context by genetically modifying zebrafish. We thus demonstrate the potential of genetic modification in the context of controlling the collective behaviour of biological active matter systems at the level of the constituents, rather than externally. In particular, we probe the effect of the lack of col11a2 gene in zebrafish, which causes the early onset of osteoarthritis. The resulting col11a2 -/- zebrafish exhibited compromised vertebral column properties, bent their body less while swimming, and took longer to change their orientations. Surprisingly, a group of 25 mutant fish exhibited more orderly collective motion than the wildtype. We show that the collective behaviour of wildtype and col11a2 zebrafish are captured with a simple active matter model, in which the mutant fish are modelled by self–propelling agents with a higher orientational noise on average. In this way, we demonstrate the possibility of tuning a biological system, changing the state space it occupies when interpreted with a simple active matter model.

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Section: Discussionmentioning

confidence: 99%