Exploring the aspect of psychosomatics in hypothyroidism: The WOMED model of body–mind interactions based on musculoskeletal changes, psychological stressors, and low levels of magnesium

Moncayo, Roy; Moncayo, Helga

doi:10.1016/j.woman.2014.02.001

Cited by 17 publications

(43 citation statements)

References 103 publications

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“…The term “The WOMED Model” refers to a combination of examination, diagnostic and therapeutical methods used routinely by us. This Model has been described and explained recently in a publication where we dealt with the topic of psychosomatics and hypothyroidism [18] . Data from this previous study (patients with hypothyroidism) was also included in the present one in order to compare them to hyperthyroidism.…”

Section: Methodsmentioning

confidence: 99%

“…The clinical examination was done as described before [8] , [10] , [18] where a central role is played by methods used in Applied Kinesiology (AK) [22] , [23] , [24] . An important addition to the previous approach is to look for any pelvic fault associated with respiratory action [22] .…”

Section: Methodsmentioning

confidence: 99%

“…In 2014 we have been able to differentiate the clinical picture of so-called psychosomatic symptoms from hypothyroidism and found these symptoms to be directly associated with magnesium deficiency. In situations of increasing physical and/or psychological stressors patients show lower magnesium levels in blood [18] . In the discussion of these findings we hypothesized that low magnesium levels would alter the function of Complex V of oxidative phosphorylation knowing that magnesium is the central player in ATP synthesis through the F 1 F O- ATPase [19] .…”

Section: Introductionmentioning

confidence: 99%

“…In this observational study we have now focused on patients with hyperthyroidism and thyroiditis applying the previously described methodology [18] . The merits of observational studies as stated by Black [20] were kept in mind in designing this study.…”

Section: Introductionmentioning

confidence: 99%

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The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

Moncayo¹,

Moncayo²

2015

BBA Clinical

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BackgroundThe aim of this study was to discern whether a relation between biochemical parameters, sonography and musculoskeletal data exists in cases of hyperthyroidism and whether they are modifiable through supplementation with selenomethionine and magnesium citrate as well as by acupuncture and manual medicine methods.ResultsA direct correlation between whole blood selenium and serum magnesium was found in subjects without thyroid disease and in menopausal women while it was reversed in cases of thyroid diseases as well as in patients with depression, infection, and in infertile women. Vascularization indices were elevated in cases of newly diagnosed benign thyroid diseases. Musculoskeletal changes i.e. lateral tension and idiopathic moving toes, as well as situations of physical and psychological stress and minor trauma and infection led to an increase of vascularization. Magnesium levels correlated negatively with these two conditions. The supplementation brought a reduction of the vascularization indices and reduced the incidence of idiopathic moving toes. Treatment of lateral tension required manual medicine methods and acupuncture (gastrocnemius). A small subgroup of patients showed a further reduction of hyper-vascularization after receiving coenzyme Q10.ConclusionsWe interpret the elevated thyroid vascularization and low magnesium levels as signs of an inflammatory process related to the musculoskeletal changes. Improvement of thyroid function and morphology can be achieved after correcting the influence of stressors together with the supplementation regime. We hypothesize that the central biochemical event in thyroid disease is that of an acquired, altered mitochondrial function due to deficiency of magnesium, selenium, and coenzyme Q10.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

Moncayo¹,

Moncayo²

2015

BBA Clinical

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“…In a previous investigation we have shown how these stressors relate to low magnesium levels [15]. The blood levels of magnesium in these subjects had a mean level 0.95 ± 0.08 mmol/l.…”

Section: How Effective Is Thyroxine Treatment? Also Known As Resolvinmentioning

confidence: 74%

Applying a systems approach to thyroid physiology: Looking at the whole with a mitochondrial perspective instead of judging single TSH values or why we should know more about mitochondria to understand metabolism

Moncayo¹,

Moncayo²

2017

BBA Clinical

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Classical thinking in endocrine physiology squeezes our diagnostic handling into a simple negative feedback mechanism with a controller and a controlled variable. In the case of the thyroid this is reduced to TSH and fT3 and fT4, respectively. The setting of this tight notion has no free space for any additions. In this paper we want to challenge this model of limited application by proposing a construct based on a systems approach departing from two basic considerations. In first place since the majority of cases of thyroid disease develop and appear during life it has to be considered as an acquired condition. In the second place, our experience with the reversibility of morphological changes makes the autoimmune theory inconsistent.While medical complexity can expand into the era of OMICS as well as into one where manipulations with the use of knock-outs and -ins are common in science, we have preferred to maintain a simple and practical approach. We will describe the interactions of iron, magnesium, zinc, selenium and coenzyme Q10 with the thyroid axis. The discourse will be then brought into the context of ovarian function, i.e. steroid hormone production. Finally the same elemental players will be presented in relation to the basic mitochondrial machinery that supports the endocrine.We propose that an intact mitochondrial function can guard the normal endocrine function of both the thyroid as well as of the ovarian axis. The basic elements required for this function appear to be magnesium and iron. In the case of the thyroid, magnesium-ATP acts in iodine uptake and the heme protein peroxidase in thyroid hormone synthesis. A similar biochemical process is found in steroid synthesis with cholesterol uptake being the initial energy-dependent step and later the heme protein ferredoxin 1 which is required for steroid synthesis. Magnesium plays a central role in determining the clinical picture associated with thyroid disease and is also involved in maintaining fertility. With the aid of 3D sonography patients needing selenium and/or coenzyme Q10 can be easily identified. By this we firmly believe that physicians should know more about basic biochemistry and the way it fits into mitochondrial function in order to understand metabolism. Contemplating only TSH is highly reductionistic.OutlineAuthor's profiles and motivation for this analysisThe philosophical alternatives in science and medicineReductionism vs. systems approach in clinical thyroid disease guidelinesThe entry into complexity: the involvement of the musculoskeletal systemIntegrating East and West: teachings from Chinese Medicine and from evidence based medicine (EBM)Can a mathematical model represent complexity in the daily thyroid practice?How effective is thyroxine treatment?Resolving the situation of residual symptoms in treated patients with thyroid diseaseImportance of iron, zinc and magnesium in relation to thyroid functionPutting together new concepts related to thyroid function for a systems approachExpanding our model into general aspects of ...

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Fluorescein Based Fluorescence Sensors for the Selective Sensing of Various Analytes

et al. 2021

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Exploring the aspect of psychosomatics in hypothyroidism: The WOMED model of body–mind interactions based on musculoskeletal changes, psychological stressors, and low levels of magnesium

Cited by 17 publications

References 103 publications

The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

Applying a systems approach to thyroid physiology: Looking at the whole with a mitochondrial perspective instead of judging single TSH values or why we should know more about mitochondria to understand metabolism

Fluorescein Based Fluorescence Sensors for the Selective Sensing of Various Analytes

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