Exploring the antioxidant effects of Aloe vera: Potential role in controlling liver function and lipid profile in high fat and fructose diet (HFFD) fed mice

Determination of cytotoxic, apoptotic, necrotic, antimicrobial and antioxidant activities of Aloe vera and Abies cilicia subsp. cilicica

“…In a study on A. vera, it was found that the administration of mice with A. vera fed a high-fat diet prevented cell damage caused by oxidative stress and dyslipidemia. It has also been reported to increase the activity of some as superoxide dismutase and catalase, which help protect cells from damage caused by oxidative stress (Abubakar et al, 2022). According to a study, extracts from A. vera leaves at a concentration of 23 µg/ml were found to inhibit the growth of the MCF-7 cancer cell line by IC50, which is significantly lower than the IC50 value against noncancerous cells (NIH-3T3) found at 332 µg/ml.…”

Network Pharmacology and Molecular Docking Study on the Multi-Target Mechanisms of Aloe vera for Non-Alcoholic Steatohepatitis Treatment

“…The KEGG analysis showed 152 pathway enrichments (Supplementary Table S4); the top 30 pathways by FDR and gene ratio are illustrated in Figure 3. Previous studies have demonstrated the anti-inflammatory, anti-apoptotic, and antioxidant effects of Aloe vera on NASH in vivo [12,18], as well as its protective roles against atherosclerosis [19] and type 2 diabetes in humans [20]. Consistent with these studies' findings, our results showed that the target pathways were mainly related to metabolic disorders (e.g., atherosclerosis, NAFLD, and insulin resistance), cell injury and death (e.g., apoptosis, TNF signaling [21], interleukin-17 signaling [22], programmed death-1 ligand 1 [PD-L1] expression, and the PD-1 checkpoint pathway [23]), oxidative stress (e.g., forkhead box O transcription factors [FOXO] signaling [24], phosphoinositide-3-kinase-protein kinase B/Akt [PI3K-AKT] signaling [25], and advanced glycation end product-receptor for advanced glycation end product [AGE-RAGE] signaling [26]), and liver fibrosis (e.g., TNF signaling, [27] The KEGG analysis showed 152 pathway enrichments (Supplementary Table S4); the top 30 pathways by FDR and gene ratio are illustrated in Figure 3.…”

“…Consistent with these studies' findings, our results showed that the target pathways were mainly related to metabolic disorders (e.g., atherosclerosis, NAFLD, and insulin resistance), cell injury and death (e.g., apoptosis, TNF signaling [21], interleukin-17 signaling [22], programmed death-1 ligand 1 [PD-L1] expression, and the PD-1 checkpoint pathway [23]), oxidative stress (e.g., forkhead box O transcription factors [FOXO] signaling [24], phosphoinositide-3-kinase-protein kinase B/Akt [PI3K-AKT] signaling [25], and advanced glycation end product-receptor for advanced glycation end product [AGE-RAGE] signaling [26]), and liver fibrosis (e.g., TNF signaling, [27] The KEGG analysis showed 152 pathway enrichments (Supplementary Table S4); the top 30 pathways by FDR and gene ratio are illustrated in Figure 3. Previous studies have demonstrated the anti-inflammatory, anti-apoptotic, and antioxidant effects of Aloe vera on NASH in vivo [12,18], as well as its protective roles against atherosclerosis [19] and type 2 diabetes in humans [20]. Consistent with these studies' findings, our results showed that the target pathways were mainly related to metabolic disorders (e.g., atherosclerosis, NAFLD, and insulin resistance), cell injury and death (e.g., apoptosis, TNF signaling [21], interleukin-17 signaling [22], programmed death-1 ligand 1 [PD-L1] expression, and the PD-1 checkpoint pathway [23]), oxidative stress (e.g., forkhead box O transcription factors [FOXO] signaling [24], phosphoinositide-3-kinase-protein kinase B/Akt [PI3K-AKT] signaling [25], and advanced glycation end product-receptor for advanced glycation end product [AGE-RAGE] signaling [26]), and liver fibrosis (e.g., TNF signaling, [27] adipocytokine signaling [28], and hypoxia-inducible factor 1 [HIF-1] signaling [29]).…”