Exploring the anti-skin inflammation substances and mechanism of Paeonia lactiflora Pall. Flower via network pharmacology-HPLC integration

Chen, Yuan; Li, Han; Zhang, Xin-Lian; Wang, Wei; Rashed, Marwan M.A.; Duan, Hong; Li, Li-Li; Zhai, Ke-Feng

doi:10.1016/j.phymed.2024.155565

Phytomedicine

2024

DOI: 10.1016/j.phymed.2024.155565

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Exploring the anti-skin inflammation substances and mechanism of Paeonia lactiflora Pall. Flower via network pharmacology-HPLC integration

Yuan Chen,

Han Li,

Xin-Lian Zhang

et al.

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2024

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Cited by 5 publications

References 41 publications

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Molecular Mechanisms of Buzhong Yiqi Decoction in the Treatment of Gastric Cancer: A Network Pharmacology, Molecular Docking, and In Vitro Experimental Analysis

Zeng,

Wu,

Chen

et al. 2024

Peptide Science

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Gastric cancer (GC) is the most common type of cancer of the digestive system with high morbidity and mortality. Chemotherapy and targeted therapy are used to treat patients with advanced GC. However, side effects and drug resistance to the two modalities remain the main challenges. The Buzhong Yiqi decoction (BZYQD), a classical traditional Chinese medicine formula, has been reported for the treatment of various types of cancers. However, the underlying pharmacological mechanism has not been fully elucidated. Therefore, this study integrated network pharmacology, molecular docking, cancer public databases, and cell experiments to explore the potential bioactive compounds and BZYQD's mechanism of action against GC. A total of 245 targets of BZYQD, 5291 GC‐related targets, and 186 were identified as their common targets through the database. Network analysis confirmed AKT1, TP53, TNF, and EGFR to be the core targets, while the main compounds observed were quercetin, kaempferol, and β‐Sitosterol. The core signaling pathways included PI3K‐AKT, MAPK, TNF, and IL‐17. Molecular docking revealed good binding activity for the main compounds and core targets. Based on the database's validation of core targets, a large number of core genes were verified to be consistent with this study. Quercetin, kaempferol, and β‐Sitosterol were found to significantly reduce the growth of GC cells in the MTT experiment. The current study revealed that BZYQD may inhibit GC progression by interfering with core targets such as AKT1, TP53, TNF, EGFR, and MAPK3, and by regulating the activity of PI3K‐AKT, MAPK, TNF, and IL‐17 signaling pathways.

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Molecular Mechanisms of Buzhong Yiqi Decoction in the Treatment of Gastric Cancer: A Network Pharmacology, Molecular Docking, and In Vitro Experimental Analysis

Zeng,

Wu,

Chen

et al. 2024

Peptide Science

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Identification and mechanistic exploration of key anti‐inflammatory molecules in American ginseng: Impacts on signal transducer and activator of transcription 3 STAT3 phosphorylation and macrophage polarization

Li,

Zhang,

Dong

et al. 2024

Phytotherapy Research

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American ginseng (AG) has been reported to have anti‐inflammatory effects in many diseases, but the key molecules and mechanisms are unclear. This study aims to evaluate the anti‐inflammatory mechanism of AG and identify the key molecules by in vivo and in vitro models. Zebrafish was employed to assess the anti‐inflammatory properties of AG and the compounds. Metabolomics was utilized to identify potential anti‐inflammatory molecules in AG, while molecular dynamics simulations were conducted to forecast the interaction capabilities of these compounds with inflammatory targets. Additionally, macrophage cell was employed to investigate the anti‐inflammatory mechanisms of the key molecules in AG by enzyme‐linked immunosorbent assay and western blotting. Seven potential anti‐inflammatory molecules were discovered in AG, with ginsenoside Rg1, ginsenoside Rs3 (G‐Rs3), and oleanolic acid exhibiting the strongest affinity for signal transducer and activator of transcription 3. These compounds demonstrated inhibitory effects on macrophage migration in zebrafish models and the ability to regulate ROS levels in both zebrafish and macrophages. The cell experiments found that ginsenoside Rg1, ginsenoside Rs3, and oleanolic acid could promote macrophage M2/M1 polarization ratio and inhibit phosphorylation overexpression of signal transducer and activator of transcription 3. This study revealed the key anti‐inflammatory molecules and mechanisms of AG, and provided new evidence of anti‐inflammatory for the scientific use of AG.

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Optimization of fermentation conditions for peptides from waste jasmine flower and its anti-aging effect on H2O2-induced normal human dermal fibroblasts

Wu,

Wei,

Feng

et al. 2024

Industrial Crops and Products

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Exploring the anti-skin inflammation substances and mechanism of Paeonia lactiflora Pall. Flower via network pharmacology-HPLC integration

Cited by 5 publications

References 41 publications

Molecular Mechanisms of Buzhong Yiqi Decoction in the Treatment of Gastric Cancer: A Network Pharmacology, Molecular Docking, and In Vitro Experimental Analysis

Molecular Mechanisms of Buzhong Yiqi Decoction in the Treatment of Gastric Cancer: A Network Pharmacology, Molecular Docking, and In Vitro Experimental Analysis

Identification and mechanistic exploration of key anti‐inflammatory molecules in American ginseng: Impacts on signal transducer and activator of transcription 3 STAT3 phosphorylation and macrophage polarization

Optimization of fermentation conditions for peptides from waste jasmine flower and its anti-aging effect on H2O2-induced normal human dermal fibroblasts

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