Exploring the Accuracy of ab Initio Prediction Methods for Viral Pseudoknotted RNA Structures
Vasco Miguel Medeiros,
Jennifer M Pearl,
Mia Carboni
et al.
Abstract:The prediction of tertiary RNA structures is significant to the field of medicine (e.g. mRNA vaccines, genome editing), and the exploration of viral transcripts. Though many RNA folding software exist, few studies have condensed their locus of attention solely to viral pseudoknotted RNA. These regulatory pseudoknots play a role in genome replication, gene expression, and protein synthesis. This study explores five RNA folding engines that compute either the minimum free energy (MFE) or the maximum expected acc… Show more
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