The paper examines the prospects and peculiarities of the development of cross-border e-commerce between Russia and China. The degree of e-commerce impact on trade turnover between Russia and China is assessed using an econometric model based on the analysis of trade flows between BRICS countries in the period from 2000 to 2022. The results obtained indicate that with an increase of 1% in the number of Internet users in Russia and its trading partners from the BRICS countries, the trade turnover increases by 0.19%. The paper also identifies the key challenges faced by entrepreneurs engaged in cross-border e-commerce between Russia and China and offers guidelines for these countries’ cooperation in the field of e-commerce. Based on the analysis of the relevant data the paper concludes that integration of digital technologies and increased access to the Internet contribute to the strengthening of trade ties between Russia and the BRICS countries, thus opening up new prospects for the development of cross-border e-commerce.